570390-00-0
中文名称
A2TI-1
英文名称
Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-
CAS
570390-00-0
分子式
C20H22N4O2S
分子量
382.48
MOL 文件
570390-00-0.mol
更新日期
2023/03/20 15:41:25
570390-00-0 结构式
基本信息
英文别名
A2ti-1Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-
物理化学性质
沸点642.4±65.0 °C(Predicted)
密度1.26±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 250 mg/mL (653.63 mM)
酸度系数(pKa)15.06±0.40(Predicted)
形态Solid
颜色White to off-white
A2TI-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-136465 | A2ti-1 | 570390-00-0 | 5mg | 2333元 |
| 2025/02/08 | HY-136465 | A2ti-1 | 570390-00-0 | 10mM * 1mLin DMSO | 2566元 |
| 2025/02/08 | HY-136465 | A2ti-1 | 570390-00-0 | 10mg | 3500元 |
常见问题列表
生物活性
A2ti-1 是选择性的，高亲和力的膜联蛋白 A2/S100A10 异四聚体 (A2t) 抑制剂，IC50 为 24 μM。A2ti-1 特异性破坏 A2 和 S100A10 之间的蛋白质相互作用。A2ti-1 可防止人乳头瘤病毒 16 型 (HPV16) 感染。靶点
IC50: 24 μM (A2t)
体外研究
A2ti-1 (compound 1 b) is an annexin A2-S100A10 protein-protein interaction blocker.
A2ti-1 (100 μM; for 72 hours) reduces HPV16 PsV infection of HeLa cells in a dose-dependent manner.
A2ti-1 (10, 25, 50, 75, 100 μM; 24 hours) significantly reduces CFDA-SE-labelled HPV16 PsV entry into HeLa cells in a dose-dependent manner.
Cell Viability Assay
| Cell Line: | HeLa cells |
| Concentration: | 100 μM |
| Incubation Time: | For 72 hours |
| Result: | Reduced HPV16 PsV infection of HeLa cells in a dose-dependent manner with 100% inhibition of infection observed at 100 μM and similar results were observed in HaCaT cells. |