| Identification | Back Directory | [Name]
Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]- | [CAS]
570390-00-0 | [Synonyms]
A2ti-1
Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]- | [Molecular Formula]
C20H22N4O2S | [MDL Number]
MFCD03737817 | [MOL File]
570390-00-0.mol | [Molecular Weight]
382.48 |
| Chemical Properties | Back Directory | [Boiling point ]
642.4±65.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (653.63 mM) | [form ]
Solid | [pka]
15.06±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 24 μM[1]. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection[2]. | [storage]
Store at -20°C | [References]
[1] Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46. DOI:10.1002/cmdc.201200107
[2] Andrew W Woodham, et al. Small Molecule Inhibitors of the Annexin A2 Heterotetramer Prevent Human Papillomavirus Type 16 Infection. J Antimicrob Chemother. 2015;70(6):1686-90. DOI:10.1093/jac/dkv045 |
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