57818-44-7
中文名称
伪-HYDROXYLINOLEIC ACID
英文名称
Voxilaprevir
CAS
57818-44-7
分子式
C18H32O3
分子量
296.44
MOL 文件
57818-44-7.mol
更新日期
2023/03/20 15:41:23
57818-44-7 结构式
基本信息
中文别名
Α-羟基油酸伪-HYDROXYLINOLEIC ACID
英文别名
ABTL0812ABTL-0812
ABTL 0812
ABTL0812 (ABTL 0812
α-Hydroxylinoleic acid
2-hydroxylinoleic acid)
ABTL 0812
2-HYDROXYLINOLEIC ACID
9,12-Octadecadienoic acid, 2-hydroxy-, (9Z,12Z)-
(9~{Z},12~{Z})-2-hydroxyoctadeca-9,12-dienoic acid
常见问题列表
生物活性
ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) 可在肺鳞癌细胞系中通过诱导TRIB3的过表达和激活自噬来抑制 Akt/mTOR 轴。ABTL0812 还可诱导 AMPK 激活和 ROS 积累。靶点
| Target | Value |
|
Akt
() | |
|
mTOR
() |
体外研究
ABTL-0812 (ABTL0812; 10-100 μM; 48 hours) inhibits cell viability of squamous NSCLC H157 cells.
Compared with squamous NSCLC H157 cells, human lung fibroblast cell line MRC-5 are resistant to ABTL0812 treatment.
Cell Viability Assay
| Cell Line: | Human lung fibroblast MRC5 and squamous non-small cell lung (NSCLC) H157 cells |
| Concentration: | 10, 30, 100 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited cell viability of squamous NSCLC H157 cells, not lung fibroblast cell line MRC-5. |
体内研究
ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress in human lung and pancreatic xenografts.
ABTL-0812 induces hallmarks of ER stress in vivo. ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively.
| Animal Model: | Athymic female nude mice bearing MiaPaca2 and A549 xenograft models |
| Dosage: | 120 mg/kg |
| Administration: | Administered by oral gavage; 5 times per week for 33 days |
| Result: | Induced ER stress in human lung and pancreatic xenografts. |