| Identification | Back Directory | [Name]
Voxilaprevir | [CAS]
57818-44-7 | [Synonyms]
ABTL0812
ABTL-0812
ABTL 0812
ABTL0812
(ABTL 0812
α-Hydroxylinoleic acid
2-hydroxylinoleic acid)
ABTL 0812;2-HYDROXYLINOLEIC ACID
9,12-Octadecadienoic acid, 2-hydroxy-, (9Z,12Z)-
(9~{Z},12~{Z})-2-hydroxyoctadeca-9,12-dienoic acid | [Molecular Formula]
C18H32O3 | [MDL Number]
MFCD31544382 | [MOL File]
57818-44-7.mol | [Molecular Weight]
296.44 |
| Chemical Properties | Back Directory | [Boiling point ]
409.7±30.0 °C(Predicted) | [density ]
0.970±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 5 mg/mL (16.87 mM) | [form ]
Liquid | [pka]
3.85±0.21(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
α-Hydroxylinoleic Acid is an anticancer drug. Could be used in combination with chemotherapy for treating nonsmall cell lung cancer. | [Definition]
ChEBI: 2-hydroxylinoleic acid is a 2-hydroxy fatty acid derived from linoleic acid. It has a role as an Arabidopsis thaliana metabolite, an antineoplastic agent, a PPARalpha agonist and a PPARgamma agonist. It is a 2-hydroxy fatty acid, a long-chain fatty acid and a HODE. It is functionally related to a linoleic acid. | [in vivo]
ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress in human lung and pancreatic xenografts[1].
ABTL-0812 induces hallmarks of ER stress in vivo. ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively[1]. | Animal Model: | Athymic female nude mice bearing MiaPaca2 and A549 xenograft models[1] | | Dosage: | 120 mg/kg | | Administration: | Administered by oral gavage; 5 times per week for 33 days | | Result: | Induced ER stress in human lung and pancreatic xenografts. |
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