60477-38-5
中文名称
Pifithrin-α, p-nitro, cyclic
英文名称
Pifithrin-α, p-nitro, cyclic
CAS
60477-38-5
分子式
C15H13N3O2S
分子量
299.35
MOL 文件
60477-38-5.mol
更新日期
2025/04/23 09:51:10
60477-38-5 结构式
基本信息
中文别名
PIFITHRIN-Α, P-NITRO, CYCLIC化合物PIFITHRIN-Α, P-NITRO, CYCLIC
5,6,7,8-四氢-2-(4-硝基苯基)咪唑并[2,1-b]苯并噻唑
英文别名
p-Nitro-CyclicPifithrin-αp-Nitro-Cyclic Pifithrin-a
Cyclic pifithrin-α-p-nitro
p-nitro-Cyclic Pifithrin-α
Pifithrin-α, p-nitro, cyclic
Pifithrin-alpha, p-Nitro, Cyclic
p-nitro Cyclic Pifithrin-.alpha.
Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem
Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-nitrophenyl)-
2-(4-Nitro-phenyl)-5,6,7,8-tetrahydro-benzo[d]imidazo[2,1-b]thiazole
物理化学性质
熔点233-234 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
密度1.53±0.1 g/cm3(Predicted)
储存条件-20C
溶解度≤1mg/ml in dimethyl formamide
酸度系数(pKa)6.14±0.20(Predicted)
形态黄色固体
颜色Light yellow to yellow
Pifithrin-α, p-nitro, cyclic价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-123076 | Pifithrin-α, p-Nitro, Cyclic | 60477-38-5 | 1 mg | 454元 |
| 2025/02/08 | HY-123076 | Pifithrin-α, p-nitro, cyclic Pifithrin-α, p-Nitro, Cyclic | 60477-38-5 | 5mg | 1000元 |
| 2025/02/08 | HY-123076 | Pifithrin-α, p-nitro, cyclic Pifithrin-α, p-Nitro, Cyclic | 60477-38-5 | 10mg | 1600元 |
常见问题列表
生物活性
Pifithrin-α, p-Nitro, Cyclic (PFN-α)，是细胞通透性的 p53 抑制剂。Pifithrin-α, p-Nitro, Cyclic 对暴露于 Etoposide 的皮层神经元的保护作用比 Pifithrin-α 强一个数量级 (ED50=30 nM)。Pifithrin-α, p-Nitro, Cyclic 也作为 p53 转录后活性抑制剂。Pifithrin-α, p-Nitro, Cyclic 不阻止 p53 上的 S15 残基磷酸化。体外研究
Pifithrin-α, p-Nitro, Cyclic (PFN-α) efficiently blocks p53-triggered cell death and p21/WAF1 expression in cortical neurons exposed to etoposide at concentrations one order magnitude lower than that in PFT-α.
体内研究
Intraocular injection of pifithrin-α slightly increases survival of retinal ganglion cell (RGC) at the concentration of 6 μM but not at 0.06 μM. Pifithrin-α, p-Nitro, Cyclic (PFN-α) is not effective in vivo, even at 6 μM.
Pifithrin-α, p-Nitro, Cyclic shows the half-life (t
1/2
) of 6 hours (when incubated in biological conditions).