64-47-1
中文名称
硫酸依色林
英文名称
ESERINE SULFATE
CAS
64-47-1
EINECS 编号
200-585-4
分子式
C30H44N6O8S
MDL 编号
MFCD06795853
分子量
648.77
MOL 文件
64-47-1.mol
64-47-1 结构式
基本信息
中文别名
硫酸毒豆碱硫酸依色林
毒扁豆碱硫酸盐
依色林硫酸盐
英文别名
(3AS)-CIS-1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRIMETHYLPYRROLO[2,3-B]INDOL-5-OL METHYLCARBAMATE HEMISULFATEESERINE HEMISULFATE
ESERINE HEMISULFATE SALT
ESERINE SULFATE
PHYSOSTIGMINE HEMISULFATE
PHYSOSTIGMINE HEMISULFATE SALT
PHYSOSTIGMINE SULFATE
(3as-cis)-amate(estersulfate(2:1)(salt)
(3as-cis)-ylcarbamate(estersulfate(2:1)
3-b)indole,1,2,3,3a,8,8a-hexahydro-5-hydroxy-1,3a,8-trimethyl-pyrrolo(meth
eserinesulphate
physostigmineso4
physostigminesulphate
Pyrrolo2,3-bindol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-, sulfate (2:1) (salt)
PHYSOSOTIGMINESULPHATE
Physostigminsulfat
(3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol methylcarbamate hemisulfate
所属类别
原料药：眼科用药物理化学性质
熔点140° (after drying at 100°)
密度1.0911 (rough estimate)
折射率1.7000 (estimate)
储存条件2-8°C
储存条件2-8°C
溶解度DMSO（微溶）、乙醇（微溶）、甲醇（微溶）
形态粉末
颜色White to off-white
水溶解性溶于水至100mM
Merck13,7469
稳定性吸湿性
常见问题列表
生物活性
Physostigmine hemisulfate (Eserine hemisulfate) 是一种可逆的乙酰胆碱酯酶 (AChE) 抑制剂。Physostigmine hemisulfate 可以透过血脑屏障并刺激中枢胆碱能神经传递。Physostigmine hemisulfate 能逆转阿尔茨海默病转基因小鼠的记忆缺陷。Physostigmine hemisulfate 也是抗胆碱能中毒的解毒剂。体内研究
Physostigmine hemisulfate (Eserine hemisulfate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice.
Physostigmine hemisulfate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats.
| Animal Model: | Heterozygous transgenic mice (Tg(+) mice) |
| Dosage: | 0.03, 0.1, and 0.3 mg/kg |
| Administration: | SC; daily for 6 weeks |
| Result: | Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals. |