65836-72-8

中文名称 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE

英文名称 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE

CAS 65836-72-8

分子式 C11H14ClNO3

分子量 243.69

MOL 文件 65836-72-8.mol

更新日期 2025/10/31 17:23:31

65836-72-8 结构式

基本信息物理化学性质安全数据图谱信息 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE价格(试剂级) 常见问题列表

基本信息

中文别名

2-氯-N-((3
4-二甲氧苯基)甲基)乙酰胺
UBA5抑制剂(DKM 2-93)
2-氯-N-(3,4-二甲氧基苄基)乙酰胺
2-氯-N-[(3,4-二甲氧苯基)甲基]乙酰胺
2-氯-N-((3,4-二甲氧苯基)甲基)乙酰胺
乙酰胺,2-氯-N-((3,4-二甲氧苯基)甲基)-

英文别名

DKM 2-93
Brn 2857211
CHEMBRDG-BB 9070724
N-(Dimethoxy-3,4 benzyl)-chloroacetamide
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french]
2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide
2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide
Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-
2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)

物理化学性质

熔点116-118 °C(Solv: carbon tetrachloride (56-23-5))

沸点425.7±45.0 °C(Predicted)

密度1.194±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO : ≥ 150 mg/mL (615.54 mM)

酸度系数(pKa)13.42±0.46(Predicted)

形态Solid

颜色White to light yellow

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS06,GHS08

警示词危险

危险性描述H301-H311-H331-H341

防范说明P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501

危险品标志Xi

危险等级IRRITANT

图谱信息

2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE(65836-72-8)核磁图(¹HNMR)

2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/05/22	HY-101836	2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93	65836-72-8	10 mg	176元
2025/05/22	HY-101836	2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93	65836-72-8	10mM * 1mLin DMSO	193元
2025/05/22	HY-101836	2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93	65836-72-8	25 mg	388元

常见问题列表

生物活性

DKM 2-93是相对选择性的UBA5抑制剂，IC50值为430 μM。

靶点

IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)

体外研究

Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC ₅₀ s of 90 and 30 μM, respectively.

体内研究

DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.