| Identification | Back Directory | [Name]
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE | [CAS]
65836-72-8 | [Synonyms]
DKM 2-93
Brn 2857211
CHEMBRDG-BB 9070724
N-(Dimethoxy-3,4 benzyl)-chloroacetamide
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide
N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french]
2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide
Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-
2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE) | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C11H14ClNO3 | [MDL Number]
MFCD01733639 | [MOL File]
65836-72-8.mol | [Molecular Weight]
243.69 |
| Chemical Properties | Back Directory | [Melting point ]
116-118 °C(Solv: carbon tetrachloride (56-23-5)) | [Boiling point ]
425.7±45.0 °C(Predicted) | [density ]
1.194±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 150 mg/mL (615.54 mM) | [form ]
Solid | [pka]
13.42±0.46(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM. | [Biological Activity]
DKM 2-93 is a relatively selective UBA5 inhibitor with IC50 value of 430 μM. | [in vitro]
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively. | [in vivo]
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity. | [target]
IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells) | [References]
[1] Roberts AM, et al. Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target. ACS Chem Biol. 2017 Apr 21;12(4):899-904. DOI:10.1021/acschembio.7b00020 |
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