66504-40-3

中文名称 1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷

英文名称 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane

CAS 66504-40-3

分子式 11H11Cl2N

分子量 228.118

MOL 文件 66504-40-3.mol

66504-40-3 结构式

基本信息物理化学性质图谱信息 1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷价格(试剂级) 常见问题列表

基本信息

中文别名

1-(3,4-二氯苯基)-3-氮杂二环[3.1.0]己烷
1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷

英文别名

DOV216303
DOV-216,303 (Free Base)
1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
3-Azabicyclo[3.1.0]hexane, 1-(3,4-dichlorophenyl)-
1-(3,4-dichlorophenyl)-3-azabicyclo(3.1.0)hexane 11H11Cl2N

物理化学性质

沸点324.4±37.0 °C(Predicted)

密度1.371

储存条件-20°C储存

溶解度DMSO : ≥ 125 mg/mL (547.96 mM);Water : < 0.1 mg/mL (insoluble)

酸度系数(pKa)10.45±0.40(Predicted)

形态Oil

颜色Colorless to light yellow

图谱信息

1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷(66504-40-3)核磁图(¹HNMR)

1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/05/22	HY-18332C	1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷 DOV-216,303 Free Base	66504-40-3	1 mg	333元
2025/05/22	HY-18332C	1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷 DOV-216,303 Free Base	66504-40-3	5mg	750元
2025/05/22	HY-18332C	1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷 DOV-216,303 Free Base	66504-40-3	10 mg	1200元

常见问题列表

生物活性

DOV-216,303 (Free Base) 是有效的 5-羟色胺、去甲肾上腺素、多巴胺再摄取的三重抑制剂，其对 hSERT、hNET 和 hDAT 的 IC50 值分别为 14 nM，20 nM和78 nM。在嗅球切除大鼠模型中，可增加前额皮质中单胺的释放及具有抗抑郁的作用。

靶点

IC50: 14 nM (serotonin), 20 nM (norepinephrine), 78 nM (dopamine).

体内研究

Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals.
Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations.

Animal Model:	Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery.
Dosage:	20 mg/kg.
Administration:	I.P. daily for 17days.
Result:	Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations.

Animal Model:	Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery.
Dosage:	20 mg/kg.
Administration:	I.P. once.
Result:	Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals.