| Identification | Back Directory | [Name]
1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane | [CAS]
66504-40-3 | [Synonyms]
DOV216303
DOV-216,303 (Free Base)
1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
3-Azabicyclo[3.1.0]hexane, 1-(3,4-dichlorophenyl)-
1-(3,4-dichlorophenyl)-3-azabicyclo(3.1.0)hexane 11H11Cl2N | [Molecular Formula]
11H11Cl2N | [MDL Number]
MFCD22381599 | [MOL File]
66504-40-3.mol | [Molecular Weight]
228.118 |
| Chemical Properties | Back Directory | [Boiling point ]
324.4±37.0 °C(Predicted) | [density ]
1.371 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 125 mg/mL (547.96 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Oil | [pka]
10.45±0.40(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively[1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[2]. | [in vivo]
Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals[2].
Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations[2]. | Animal Model: | Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery[2]. | | Dosage: | 20 mg/kg. | | Administration: | I.P. daily for 17days. | | Result: | Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations. |
| Animal Model: | Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery[2]. | | Dosage: | 20 mg/kg. | | Administration: | I.P. once. | | Result: | Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals. |
| [storage]
Store at -20°C | [References]
[1] Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. DOI:10.1016/j.bmcl.2011.01.016
[2] Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61. DOI:10.1095/biolreprod44.3.561 |
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| Company Name: |
SPIRO PHARMA
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| Telephone: |
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| Website: |
www.spiropharma.com.cn |
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