6673-35-4
6673-35-4 结构式
基本信息
中文别名
心得宁醋心安
醋氨心安
普拉洛尔
N-[4-[2-羟基-3-[(1-甲基乙基)氨基]丙氧基]苯基]乙酰胺
英文别名
dalzicay21011
eraldin
ici50172
PRACTOLOL
practalol
praktololu
dl-Practolol
rac Practolol
RaceMic Practolol
物理化学性质
熔点134-136° (BuOAc)
沸点409.54°C (rough estimate)
密度1.0807 (rough estimate)
折射率1.5110 (estimate)
酸度系数(pKa)pKa 9.5 (Uncertain)
常见问题列表
生物活性
Practolol 是一种有效和选择性的 β1 肾上腺素能受体拮抗剂。Practolol 可用于心律失常的研究。靶点
β1-adrenergic receptor
体外研究
Practolol (10 μM; 30 min) preferentially antagonizes the relaxant effects produced by R0363 in spontaneously contracted tracheal preparations from the guinea-pig.
Practolol (10 nM-100 μM) blocks the progesterone production induced by (-)epinephrine in a dose-dependent manner in granulosa cells.
体内研究
Practolol (0.5 mg/kg; i.v.) decreases heart rate, left ventricular
dP/dt max
, myocardial blood flow and cardiac output in intact close-chest dogs.
Practolol (0.5 mg/kg; i.v.) decreases normal myocardial blood flow but flow in the ischaemic area remains unchanged after coronary artery ligation.