基本信息
中文别名
氨甲酰甲胆碱苯乙二酚-D6
氨甲酰甲胆碱-D6
英文别名
BETHANECOLCarbamyl-β-methylcholine
Carbamoyl-β-methylcholine
1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-
Ammonium, (2-hydroxypropyl)trimethyl-, carbamate (ester) (8CI)
常见问题列表
生物活性
Bethanechol 是一种拟副交感神经剂。Bethanechol 是毒蕈碱型受体 (mAChR) 的激动剂，通过直接刺激副交感神经系统的 mAChR (M1、M2、M3、M4、M5) 发挥其作用。靶点
mAChR
体外研究
Bethanechol (0.3-300 μM) significantly reduces ileal pacemaker potentials, significantly.
体内研究
Bethanechol (2-12 mg/kg; i.p.) induces drinking and increased urine output of rats in a dose-dependent fashion.
| Animal Model: | Female rats of the Blue Spruce Farms (Sprague-Dawley) (280-330 g) |
| Dosage: | 2 mg/kg, 4 mg/kg, 8 mg/kg, 12 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Increased water intake during the first hr in a dose-dependent fashion up to the highest dose administered (12 mg/kg). |