基本信息
中文别名
阿氯米松 英文别名
VadermAlclometasone
AlcloMethasone
ALCLOMETHASONE DIPROPIONATE
7α-Chloro-16α-methylprednisolone
7α-Chloro-16α-methyl Prednisolone
7α-Chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
(7α,11β,16α)-7-Chloro-11,17,21-trihydroxy-16-Methylpregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 7-chloro-11,17,21-trihydroxy-16-methyl-, (7α,11β,16α)-
物理化学性质
熔点176-179°
比旋光度D26 +47.5° (c = 0.3 in DMF)
沸点607.1±55.0 °C(Predicted)
密度1.34±0.1 g/cm3(Predicted)
酸度系数(pKa)12.30±0.70(Predicted)
常见问题列表
生物活性
Alclometasone (7a-Chloro-16a-methyl prednisolone) 是一种糖皮质激素 (glucocorticoid)，可抑制白细胞促炎性介质的释放。Alclometasone 可用于缓解皮质类固醇反应性皮肤病，包括特应性皮炎，湿疹，牛皮癣和过敏性皮炎。靶点
IC50: glucocorticoid receptor
体内研究
The prodrug of alclometasone is alclometasone dipropionate.Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice.