67483-13-0
中文名称
4,4'-二异硫氰酸基-2,2'-二苯乙烯磺酸二钠[蛋白质改性试剂]
英文名称
DIDS
CAS
67483-13-0
分子式
C16H8N2Na2O6S4
分子量
498.48
MOL 文件
67483-13-0.mol
更新日期
2023/03/20 15:41:19
67483-13-0 结构式
基本信息
中文别名
DIDS4,4'-二异硫氰酰-2,2'-二磺酸二钠盐晶体
4,4'-二异硫氰酸基-2,2'-二苯乙烯磺酸二钠
4,4'-二异硫氰酸基-2,2'-二苯乙烯磺酸二钠[蛋白质改性试剂]
英文别名
DIDSDIDS,90%
DIDS DISODIUM SALT
DIDS (sodium salt)
Hydrate [Protein Modification Reagent]
4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID, 2NA
DISODIUM 4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONATE
4,4'-diisothiocyanato-2,2'-stilbenedisulfonic acid sodium
4,4'-DIISOTHIOCYANOSTILBENE-2,2'-SUFONIC ACID SODIUM SALT
4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC A. NA2-SLT HY
所属类别
生物化工：荧光成像物理化学性质
熔点>300°C
密度1.54
储存条件2-8°C
储存条件2-8°C
溶解度0.1 M potassium bicarbonate: 50 mg/mL
溶解度0.1 M 碳酸氢钾：50 mg/mL
形态powder
颜色yellow
稳定性建议在-20°C下干燥储存
CAS 数据库67483-13-0
安全数据
警示词警告
危险性描述H315-H319
危险品标志Xn
危险类别码36/37/38-42-26-22
危险类别码36/37/38-42-26-22
安全说明22-26-36/37/38
安全说明22-26-36/37/38
WGK Germany3
WGK Germany3
海关编码29309090
常见问题列表
生物活性
DIDS sodium salt (MDL101114ZA) 是 ABCA1 和 VDAC1 的双抑制剂。靶点
ABCA1, VDAC1.
体外研究
Concentration less than 400 μM DIDS has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. At the concentration of 400 μM DIDS itself slightly decreases the cell viability, although there is no significant statistic difference as compared with the untreated control. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation.