76135-31-4
中文名称
7-(二丙基氨基)-5,6,7,8-四氢-1-萘酚氢溴酸盐
英文名称
8-OH-DPAT·hydrobromide
CAS
76135-31-4
分子式
C16H25NO.BrH
分子量
328.291
MOL 文件
76135-31-4.mol
更新日期
2023/11/29 15:51:35
76135-31-4 结构式
基本信息
中文别名
8-羟基-2-二丙氨基四氢萘溴酸盐7-(二丙基氨基)-5,6,7,8-四氢-1-萘酚氢溴酸盐
英文别名
8-OH-DPAT HRrSerotonin agonist DPAT
Hydroxy-DPAT hydrobromide, 8-
3-(Dipropylamino)tetralin-5-ol·hydrobrominate
rac-8-Hydroxy-2-dipropylaMinotetralin HydrobroMide
(+/-)-8-Hydroxy(N,N-dipropyl-2-aMino)tetralin HydrobroMide
7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide
7-(DipropylaMino)-5,6,7,8-tetrahydro-1-naphthalenol HydrobroMide
1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-, hydrobromide (1:1)
7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide76135-31-4
常见问题列表
生物活性
8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) 是一种有效的,选择性 5-HT1A 激动剂,pIC50 为 8.19。8-Hydroxy-DPAT hydrobromide 对 5-HT1 结合位点的亚型具有近 1000 倍的选择性。靶点
5-HT 1A Receptor 8.19 (pIC 50 ) |
体外研究
8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) has no effect on 5-HT
1B
binding at concentrations lower than 100 nM.
体内研究
8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide; 32, 56, 80, 100 mg/kg; intramuscularly; 15 min prior to the testing session) of the highest dose significantly interferes with sustained attention and reinforcer efficacy (progressive ratio; PR) performance in the 3,4-methylenedioxymethamphetamine (MDMA)-exposed but not control animals.