| Identification | Back Directory | [Name]
8-OH-DPAT·hydrobromide | [CAS]
76135-31-4 | [Synonyms]
8-OH-DPAT HRr
Serotonin agonist DPAT
Hydroxy-DPAT hydrobromide, 8-
3-(Dipropylamino)tetralin-5-ol·hydrobrominate
rac-8-Hydroxy-2-dipropylaMinotetralin HydrobroMide
(+/-)-8-Hydroxy(N,N-dipropyl-2-aMino)tetralin HydrobroMide
7-(DipropylaMino)-5,6,7,8-tetrahydro-1-naphthalenol HydrobroMide
7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide
1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-, hydrobromide (1:1)
7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide76135-31-4 | [Molecular Formula]
C16H25NO.BrH | [MDL Number]
MFCD00055158 | [MOL File]
76135-31-4.mol | [Molecular Weight]
328.291 |
| Hazard Information | Back Directory | [Uses]
Dopamine receptor Agonist. | [Biological Activity]
The standard selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. | [in vivo]
8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide (32, 56, 80, 100 mg/kg; intramuscularly; 15 min prior to the testing session) of the highest dose significantly interferes with sustained attention and reinforcer efficacy (progressive ratio; PR) performance in the 3,4-methylenedioxymethamphetamine (MDMA)-exposed but not control animals[1].
| [IC 50]
5-HT1A Receptor: 8.19 (pIC50) | [storage]
Store at -20°C |
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