783292-37-5
783292-37-5 结构式
基本信息
中文别名
阿巴卡韦杂质4阿巴卡韦杂质D
阿巴卡韦EP杂质D
英文别名
(Abacavir EP Impurity D)Abacavir Impurity 4(Abacavir EP Impurity D)
[(1R,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enyl]methanol
(1R,?4R)?-?rel-4-?[2-Amino-?6-?(cyclopropylamino)?-?9H-?purin-?9-?yl]?-?2-?cyclopentene-?1-?methanol
应用领域
用途一
(1R,?4R)?-?rel-4-?[2-Amino-?6-?(cyclopropylamino)?-?9H-?purin-?9-?yl]?-?2-?cyclopentene-?1-?methanol (Abacavir EP Impurity D) is an impurity of Abacavir A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.