861139-16-4
中文名称
861139-16-4
英文名称
N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzenesulfonamide
CAS
861139-16-4
分子式
C20H21N5O4S
分子量
427.48
MOL 文件
861139-16-4.mol
更新日期
2025/11/17 09:45:53
861139-16-4 结构式
基本信息
中文别名
化合物RSV-IN-1 英文别名
RSV-IN-1N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzenesulfonamide
Benzenesulfonamide, N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl-1,2,4-triazolo[3,4-a]phthalazin-3-yl)-
物理化学性质
密度1.43±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : 125 mg/mL (292.41 mM);Water : < 0.1 mg/mL (insoluble)
酸度系数(pKa)14.21±0.10(Predicted)
形态Solid
861139-16-4价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-112673 | RSV-IN-1 | 861139-16-4 | 1 mg | 1028元 |
| 2025/05/22 | HY-112673 | 861139-16-4 RSV-IN-1 | 861139-16-4 | 5mg | 2996元 |
| 2025/05/22 | HY-112673 | 861139-16-4 RSV-IN-1 | 861139-16-4 | 10mM * 1mLin DMSO | 3295元 |
常见问题列表
生物活性
RSV-IN-1 是人呼吸道合胞病毒 (hRSV) 的抑制剂，其 IC50 值为 0.11 μM。靶点
IC50: 0.11μM (hRSV).
体外研究
The concentration of P13 that reduces the number of RSV plaques in HEp-2 cells by 50% (IC 50 ) is 0.11 μM. The concentration of P13 that reduces the viability of HEp-2 by 50% (CC 50 ) is 310 μM. Note that some cytotoxicity of P13 observed at 500 μM might be due to DMSO solvent. Hence, the selective index (CC 50 /IC 50 ) values is 2818 for P13. Note that even at the relatively high concentrations P13 does not completely block the development of RSV plaques. These escape plaques are of smaller size and of non-syncytial phenotype as compared to plaques formed in the absence of inhibitor.