874460-46-5
中文名称
(2R,3S)-2-[(1R)-1-[3,5-双(三氟甲基)苯基]乙氧基]-3-(苯基)吗啉盐酸盐
英文名称
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride
CAS
874460-46-5
分子式
C20H20ClF6NO2
分子量
455.83
MOL 文件
874460-46-5.mol
更新日期
2023/12/04 13:29:28
874460-46-5 结构式
基本信息
中文别名
阿瑞匹坦杂质7阿瑞吡坦杂质18
阿瑞匹坦杂质36
阿瑞匹坦杂质SM3QF
阿瑞匹坦杂质 3 HCL
(2R,3S)-2-[(1R)-1-[3,5-双(三氟甲基)苯基]乙氧基]-3-(苯基)吗啉盐酸盐
英文别名
Aprepitant Impurity SM3QFAprepitant Impurity 7 HCl
Aprepitant Impurity 3 HCl
Des-(4-fluoro-1,2,4-triazol-3-one-5-methyl (2R,3S,1'S)-Aprepitant Hydrochloride
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride
所属类别
分析化学：药典标准品和杂质标准品应用领域
用途一
Des-(4-fluoro-1,2,4-triazol-3-one-5-methyl (2R,3S,1''S)-Aprepitant Hydrochloride is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.