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881851-50-9

中文名称 H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
英文名称 Larazotide
CAS 881851-50-9
分子式 C34H59N9O12
分子量 785.885
MOL 文件 881851-50-9.mol
更新日期 2025/10/31 16:56:52
881851-50-9 结构式 881851-50-9 结构式

基本信息

中文别名
LARAZOTIDE ACETATE (>
90%)
英文别名
Larazotide acetate
LARAZOTIDE ACETATE (> 90%)
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
所属类别
有机原料：羧酸类化合物及衍生物

物理化学性质

熔点>231°C (dec.)
储存条件Refrigerator
溶解度可微溶于水
形态固体
颜色白色
InChIKeyNYGCNONRVCGHAT-FTIBEKKFNA-N
SMILESC(O)(=O)C.C(O)(=O)CNC([C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(CNC(CN)=O)=O)C(C)C)CC(C)C)C(C)C)CCC(N)=O)=O |&1:10,17,21,25,29,r|

H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH价格(试剂级)

H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2025/05/22HY-106268AH-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
Larazotide acetate		881851-50-91mg586元
2025/05/22HY-106268AH-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
Larazotide acetate		881851-50-95mg997元
2025/05/22HY-106268AH-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
Larazotide acetate		881851-50-910mg1620元

常见问题列表

生物活性
Larazotide acetate 是一种合成肽，是一种紧密连接 (junction) 的调节剂。
靶点

Paracellular permeability

体外研究

Larazotide acetate inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Further, apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.

体内研究

When tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice, larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure.

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