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890-38-0

中文名称 2'-脱氧肌苷
英文名称 2'-Deoxyinosine
CAS 890-38-0
EINECS 编号 212-964-1
分子式 C10H12N4O4
MDL 编号 MFCD00005762
分子量 252.23
MOL 文件 890-38-0.mol
更新日期 2024/03/25 09:24:15
890-38-0 结构式 890-38-0 结构式

基本信息

中文别名
2ˊ-脱氧次黄嘌呤核苷
2ˊ-脱氧肌苷
9-(2-脱氧-Β-D-呋喃核糖基)次黄嘌呤
英文别名
2'-DEOXYINOSINE
9-(2-DEOXY-BETA-D-RIBOFURANOSYL)HYPOXANTHINE
DEOXYINOSINE, 2'-
DI
2’-deoxy-inosin
Deoxyinosine
Hypoxanthine, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-
9-(2-deoxy-β-d-ribofuranosyl)hypoxanthine
2'-Deoxy-D-inosine
9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
DEOXYINOSINE, 2'-(P)
2''-DEOXYINOSINE Crystalline
9-(4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydropurin-6-one
2-DEOXYINOSINE extrapure
9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Inosine, 2'-deoxy-
所属类别
生物化工:核苷酸及其类似物

物理化学性质

外观性状白色粉末,可溶于甲醇、乙醇、DMSO等有机溶剂。
熔点250 °C
比旋光度21 º (c=1, H2O 22 ºC)
沸点395.4°C (rough estimate)
密度1.3402 (rough estimate)
折射率-16 ° (C=1, H2O)
储存条件−20°C
溶解度DMSO (Slightly), Waterh (Slightly)
酸度系数(pKa)8.92±0.70(Predicted)
形态粉末
颜色白色至灰白色
水溶解性8.33g/L(25.02 ºC)
BRN33517
InChIInChI=1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1
InChIKeyVGONTNSXDCQUGY-RRKCRQDMSA-N
SMILESOC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)O)N=C2)C[C@@H]1O
NIST化学物质信息Inosine, 2'-deoxy-(890-38-0)

安全数据

危险性符号(GHS)
GHS07
警示词警告
危险性描述H302-H315-H319
危险品标志Xn,Xi
危险类别码20/21/22-36/37/38
安全说明S24/25
WGK Germany3
海关编码29349990

化学品安全说明书(MSDS)

常见问题列表

生物活性
2’-deoxyadenosine 能够抑制人癌细胞株的生长,并发现其与嘌呤核苷磷酸化酶 (PNP) 缺乏有关。
靶点

Human Endogenous Metabolite

体外研究

In the absence of deoxycoformycin, 2’-deoxyadenosine is primarily deaminated to 2’-deoxyinosine and then converted into hypoxanthine. In the presence of the inhibitor, the deoxynucleoside, in addition to a phosphorylation process, undergoes phosphorolytic cleavage giving rise to adenine. The conversion of 2’-deoxyadenosine to adenine might represent a protective device, emerging when the activity of adenosine deaminase is reduced or inhibited. There is much evidence to indicate that the enzyme catalyzing this processs may be distinct from methylthioadenosine phosphorylase and S-adenosyl homocysteine hydrolase, which are the enzymes reported to be responsible for the formation of adenine from 28-deoxyadenosine in mammals.

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