896705-16-1
中文名称
BMH-21
英文名称
BMH21
CAS
896705-16-1
分子式
C21H20N4O2
更新日期
2025/04/22 17:41:27
分子量
360.41
MOL 文件
896705-16-1.mol
896705-16-1 结构式
基本信息
中文别名
RNA POLYMERASE I转录抑制剂(BMH-21)N-(2-(二甲氨基)乙基)-12-氧代-12H-苯并[G]吡啶并[2,1-B]喹唑啉-4-甲酰胺
N-[2-(二甲基氨基)乙基]-12-氧代-12H-苯并[G]吡啶并[2,1-B]喹唑啉-4-甲酰胺
英文别名
BMH21CS-1749
BMH-21, >98%
BMH 21
BMH21
BMH21 USP/EP/BP
N-[2-(Dimethylamino)ethyl]-12-oxo-5,13-diazatetracene-4-carboxamide
N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo-
BMH-21 N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
所属类别
生物化工：DNA/RNA Synthesis 抑制剂物理化学性质
密度1.28±0.1 g/cm3(Predicted)
储存条件2-8°C
溶解度DMSO：可溶1mg/mL，澄清（加热）
酸度系数(pKa)7.90±0.20(Predicted)
形态粉末
颜色淡黄色至深黄色
常见问题列表
生物活性
BMH-21是一种DNA嵌入剂，与核糖体DNA结合，并抑制RNA polymerase I (Pol I)转录。体外研究
BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability.体内研究
BMH-21 reduces tumor growth in mouse xenografts.