89750-14-1
中文名称
glucagon-like peptide 1
英文名称
glucagon-like peptide 1
CAS
89750-14-1
分子式
C149H226N40O45
分子量
3297.63
MOL 文件
89750-14-1.mol
更新日期
2026/02/01 21:48:05
89750-14-1 结构式
物理化学性质
序列H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
应用领域
多肽
胰高血糖素样肽是人体分泌的一种肠道激素，由胰高血糖素原(Proglucagon)分子经肠道蛋白水解酶作用而产生，因而称为胰高血糖素类多肽。胰高血糖素样肽-1是由30个氨基酸残基组成的多肽，肽链C端乙酰化；另一种为GLP-1(7-37)，是由31个氨基酸残基组成的多肽。GLP-1(7-36)和GLP-1(7-37)有相同的促胰岛素分泌作用。研究表明当血糖浓度高于6mmol/L时，GLP-1能显著促进胰岛素分泌；而一旦血糖浓度恢复至正常值则不再继续作用，在临床上这一点对II型糖尿病的治疗十分有用。用途一
GLP-1 stimulates pancreatic β cells to secrete insulin as
an incretin hormone. GLP-1 also has additional actions,
including suppression of glucagon secretion, inhibition of
gastric motility, and promotion of satiety. GLP-1 was first identified in the early 1980s, following
the cloning of the proglucagon gene. The biological activity of GLP-1 was investigated initially by using the
N-terminal extended forms of GLP-1(1–37 and 1–36
amide). However, these forms were devoid of biological
activity. In the late 1980s, bioactive GLP-1 peptides were
purified from gut extracts and were identified to be GLP-1(7–37) and GLP-1(7–36)-amide. In the current literature,
the unqualified designation of GLP-1 corresponds to the
truncated peptides.参考质量标准
外观:白色粉末纯度(HPLC) ≥95.0%
醋酸根含量5.0%～12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%