90614-48-5
中文名称
抑二肽素A
英文名称
DIPROTIN A
CAS
90614-48-5
分子式
C17H31N3O4
MDL 编号
MFCD00038707
分子量
341.45
MOL 文件
90614-48-5.mol
更新日期
2024/04/22 16:27:22
90614-48-5 结构式
物理化学性质
沸点583.1±50.0 °C(Predicted)
密度1.140±0.06 g/cm3(Predicted)
储存条件−20°C
储存条件-20°C
溶解度DMSO:250.0(Max Conc. mg/mL);732.17(Max Conc. mM)
Water:67.08(Max Conc. mg/mL);196.44(Max Conc. mM)
Water:67.08(Max Conc. mg/mL);196.44(Max Conc. mM)
酸度系数(pKa)3.72±0.22(Predicted)
形态白色至类白色固体
水溶解性Soluble in water at 1mg/ml
常见问题列表
生物活性
Diprotin A (Ile-Pro-Ile) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。靶点
IC50: DPP-IV
体外研究
Diprotin A (100 μM; 30 minutes after CXCR4-blocker or Src-inhibitor treatment) induces the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs in both normoxia and H/R conditions in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor.
Western Blot Analysis
| Cell Line: | Human endothelial cells [1] |
| Concentration: | 100 μM |
| Incubation Time: | 30 minutes after CXCR4-blocker or Src-inhibitor treatment |
| Result: | Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs. |
体内研究
Diprotin A (intraperitoneal injection; 70 μg/kg; twice daily; 7 days) increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
| Animal Model: | Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice |
| Dosage: | 70 μg/kg |
| Administration: | Intraperitoneal injection; twice daily; 7 days |
| Result: | Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway. |