912-60-7
912-60-7 结构式
基本信息
盐酸那可汀
盐酸那可丁
那可丁盐酸盐
那可汀鹼鹽酸鹽
那可汀 盐酸盐
那可汀盐酸盐水合物
那可丁盐酸盐水合物
那可丁盐酸盐一水合物
诺司卡品 盐酸盐 水合物
opianhydrochloride
capvalhydrochloride
lyobexhydrochloride
nsc5366hydrochloride
vadebexhydrochloride
NOSCAPINE BASE / HCL
coscopinhydrochloride
longatinhydrochloride
nectadonhydrochloride
物理化学性质
常见问题列表
Sigma opioid receptors Bradykinin Apoptosis
Noscapine (0-1000 μM; 0-96 hours; rat C6 glioma cells) treatment inhibits cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. Noscapine inhibits the viability of rat C6 glioma cells with an IC
50
of 250 μM at 72 hours.
Noscapine exposure causes abnormal S-phase reentry, increases mitotic arrest and results in excessive DNA accumulation.
Cylindromatosis increases the ability of noscapine to induce mitotic arrest and apoptosis. Cylindromatosis enhances the effect of noscapine on microtubule polymerization and promotes noscapine binding to microtubules.
Cell Proliferation Assay
| Cell Line: | Rat C6 glioma cells |
| Concentration: | 0 μM, 0.1 μM, 1 μM, 2 μM, 10 μM, 50 μM, 100 μM, 1000 μM |
| Incubation Time: | 0 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours |
| Result: | Inhibited cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. |
Noscapine (300 mg/kg; oral gavage; daily; for 15 days; athymic female mice) treatment reduces tumor growth in mice.
| Animal Model: | Athymic female mice (nu/nu) (8-week-old) injected with rat C6 glioma cells |
| Dosage: | 300 mg/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Revealed a significant reduction of tumor volume. |