吡啶-3-乙炔
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- CAS号:
- 120241-79-4
- 英文名:
- Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI)
- 英文别名:
- 3-TYP;CS-2754;Pyridine(3-TYP);3-TYP;3 TYP;3TYP;3-TYP, 10 mM in DMSO;3-triazol-4-yl) pyridine;3-(1H-1,2,3-triazol-4-yl)pyridine;3-(2H-1,2,3-triazol-4-yl)pyridine;3-(1H-1,2,3-triazol-5-yl)pyridine;Pyridine,3-(1H-1,2,3-triazol-5-yl)-
- 中文名:
- 吡啶-3-乙炔
- 中文别名:
- 吡啶-3-乙炔;化合物3-TYP;3-(1H-1,2,3-三唑-4-)砒啶;3-(1H-1,2,3-噻唑-4-基)吡啶;3-(1H-1,2,3-三唑-4-基)吡啶;3-(1H-1,2,3-三唑-5-基)吡啶;化合物3-TYP,10 MM DMSO 溶液
- CBNumber:
- CB01069415
- 分子式:
- C7H6N4
- 分子量:
- 146.15
- MOL File:
- 120241-79-4.mol
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吡啶-3-乙炔化学性质
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熔点:
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180-182 °C(Solv: ethyl acetate (141-78-6); ethyl ether (60-29-7))
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沸点:
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386.6±17.0 °C(Predicted)
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密度:
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1.296±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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7.54±0.70(Predicted)
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颜色:
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White to off-white
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吡啶-3-乙炔性质、用途与生产工艺
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) 是SIRT3的选择性抑制剂，相对于Sirt1和Sirt2来说，对Sirt3具有较高选择性。对SIRT1、SIRT2、SIRT3的IC50分别为88 nM、92 nM、16 nM。
| Target | Value |
SIRT3
(cell-free)
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16 nM
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SIRT1
(cell-free)
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88 nM
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SIRT2
(cell-free)
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92 nM
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在暴露于镉的HepG2细胞中，3-TYP可减弱由褪黑色素诱导的去乙酰化SOD2表达增加及抑制SOD2活性。
3-TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group.
吡啶-3-乙炔
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-108331 | 吡啶-3-乙炔
3-TYP | 120241-79-4 | 5mg | 600元 |
| 2025/05/22 | HY-108331 | 吡啶-3-乙炔
3-TYP | 120241-79-4 | 10mM * 1mLin DMSO | 660元 |
120241-79-4, 吡啶-3-乙炔 相关搜索:
- PYRIDINE
- API
- 抑制剂
- 药靶配体
- 化合物3-TYP,10 MM DMSO 溶液
- 3-(1H-1,2,3-三唑-4-)砒啶
- 3-(1H-1,2,3-噻唑-4-基)吡啶
- 化合物3-TYP
- 3-(1H-1,2,3-三唑-4-基)吡啶
- 3-(1H-1,2,3-三唑-5-基)吡啶
- 吡啶-3-乙炔
- 120241-79-4
- 3-TYP, 10 mM in DMSO
- 3-(1H-1,2,3-triazol-5-yl)pyridine
- 3-(2H-1,2,3-triazol-4-yl)pyridine
- Inhibitor,3-TYP,3TYP,3 TYP,inhibit,Sirtuin
- Pyridine, 3-(1H-1,2,3-triazol-4-yl)-
- Pyridine,3-(1H-1,2,3-triazol-5-yl)-
- 3-triazol-4-yl) pyridine
- 3-(1H-1;2;3-TRIAZOL-4-YL) PYRIDINE;3 TYP;3TYP
- CS-2754
- 3-TYP;3 TYP;3TYP
- Pyridine(3-TYP)
- 3-TYP
- 3-(1H-1,2,3-triazol-4-yl)pyridine
- Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI)