外消旋-莫地帕泛
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- CAS号:
- 122956-68-7
- 英文名:
- modipafant
- 英文别名:
- UK-74505;Modipefant;rac-Modipafant;Modipafant racemate;(Rac) Modipafant,(Rac)Modipafant;ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl)-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate(WXG02205);4-(2-Chlorophenyl)-1,4-dihydro-6-Methyl-2-[4-(2-Methyl-1H-iMidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylaMino)carbonyl]-3-pyridinecarboxylic Acid Ethyl Ester;2-[4-(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-4-(2-chlorophenyl)-5-[(2-pyridinylamino)carbonyl]-6-methyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester
- 中文名:
- 外消旋-莫地帕泛
- 中文别名:
- 外消旋-莫地帕泛;化合物 T28081;2-[4-(2-甲基-1H-咪唑并[4,5-C]吡啶-1-基)苯基]-4-(2-氯苯基)-5-[(2-吡啶基氨基)羰基]-6- 甲基-1,4-二氢吡啶-3-羧酸乙酯
- CBNumber:
- CB01310883
- 分子式:
- C34H29ClN6O3
- 分子量:
- 605.09
- MOL File:
- 122956-68-7.mol
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外消旋-莫地帕泛化学性质
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密度:
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1.34±0.1 g/cm3 (20 ºC 760 Torr)
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储存条件:
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Store at -20°C
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酸度系数(pKa):
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12.14±0.70(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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外消旋-莫地帕泛性质、用途与生产工艺
(Rac)-Modipafant (UK-74505) 是一种口服的、选择性的、长效的不可逆血小板活化因子受体 (PAFR) 受体拮抗剂。(Rac)-Modipafant 预防严重登革热感染。
(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection.
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC
50
=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively).
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia.
Animal Model:
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8- to 10-week-old BALB/c mice (DEN-2 strain infected)
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Dosage:
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10 mg/kg
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Administration:
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P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10
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Result:
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Decreased by approximately 50% the lethality associated with DEN-2 infection.
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Animal Model:
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Male BALB/C (8- to 10- week-old) wild-type mice
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Dosage:
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5, 10 and 20 mg/kg
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Administration:
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P.o.
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Result:
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Dose-dependently inhibited the Zymosan -induced articular hyperalgesia.
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外消旋-莫地帕泛
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-108908 | (Rac)-Modipafant | | 1 mg | 3400元 |
2024/08/19 | HY-108908 | 外消旋-莫地帕泛 (Rac)-Modipafant | 122956-68-7 | 5 mg | 8500元 |
122956-68-7, 外消旋-莫地帕泛 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Amines
- 化合物 T28081
- 2-[4-(2-甲基-1H-咪唑并[4,5-C]吡啶-1-基)苯基]-4-(2-氯苯基)-5-[(2-吡啶基氨基)羰基]-6- 甲基-1,4-二氢吡啶-3-羧酸乙酯
- 外消旋-莫地帕泛
- 122956-68-7
- (Rac) Modipafant,(Rac)Modipafant
- Modipafant racemate
- 3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester
- ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl)-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate(WXG02205)
- rac-Modipafant
- 4-(2-Chlorophenyl)-1,4-dihydro-6-Methyl-2-[4-(2-Methyl-1H-iMidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylaMino)carbonyl]-3-pyridinecarboxylic Acid Ethyl Ester
- UK-74505
- Modipefant
- 2-[4-(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-4-(2-chlorophenyl)-5-[(2-pyridinylamino)carbonyl]-6-methyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester