SR 33805
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- CAS号:
- 121345-64-0
- 英文名:
- SR 33805
- 英文别名:
- SR 33805;Ca channels,channel,failing,Ca2+ channels,Ca2+,SR 33805,Calcium Channel,acute,L-type,SR-33805,Inhibitor,inhibit,depolarized,polarized,hearts,chronic,SR33805
- 中文名:
- SR 33805
- 中文别名:
- 化合物SR33805;3,4-二甲氧基-N-甲基-N-[3-[4-[[1-甲基-2-2-(1-甲基乙基))-1H-吲哚-‐3-基]磺酰基]苯氧基]丙基]苯乙胺
- CBNumber:
- CB01400869
- 分子式:
- C32H40N2O5S
- 分子量:
- 564.7354
- MOL File:
- 121345-64-0.mol
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SR 33805性质、用途与生产工艺
SR33805 是一种有效的 Ca2+ 通道拮抗剂，在去极化和极化条件下的 EC50 值分别为 4.1 nM 和 33 nM。SR33805 阻止 L 型而不是 T 型 Ca2+ 通道。SR33805 可用于研究急性或慢性心脏衰竭。
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L-type calcium channel
4.1 nM (EC
50
, in depolarized conditions)
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L-type calcium channel
33 nM (EC
50
, in polarized conditions)
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SR33805 (0.01-10 µM; 3 d) inhibits growth factor-induced proliferation of SMC (0.20
50<0.46 µM) in a dose-dependent manner.
SR33805 (10 µM; 10 min) restores the myocardial infarction (MI)-altered cell shortening without affecting the Ca
2+
transient amplitude.
SR33805 (10 µM) decreases the activity of recombinant PKA.
Cell Viability Assay
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Cell Line:
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Smooth muscle cells (SMC)
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Concentration:
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0.01, 0.1, 1, 10 µM
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Incubation Time:
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3 days
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Result:
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Inhibited in a dose-dependent manner FCS-, bFGF and PDGF-induced proliferation of porcine SMC with IC
50
s of 0.26±0.08, 0.46±0.1 and 0.20±0.04 µM, respectively.
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SR33805 (20 mg/kg; a single i.p.) improves end-systolic strain and fractional shortening of MI hearts in rats.
SR33805 (5 mg/kg/day; p.o. for 38 d) significantly reduces intimal hyperplasia in pigs.
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Animal Model:
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Male Wistar rats (5 weeks) are subjected to coronary artery ligature
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Dosage:
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0.2, 2, 20 mg/kg
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Administration:
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A single i.p. injection
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Result:
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Increased significantly both end-systolic strain (ESS) and fractional shortening (FS) by about +38 and +26%, respectively at the dose of 20 mg/kg.
Did not affect other contractile parameters.
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SR 33805
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-136909 | SR33805 | | 1 mg | 685元 |
| 2024/04/30 | HY-136909 | SR 33805
SR33805 | 121345-64-0 | 10mg | 3000元 |
121345-64-0, SR 33805 相关搜索:
- 3,4-二甲氧基-N-甲基-N-[3-[4-[[1-甲基-2-2-(1-甲基乙基))-1H-吲哚-‐3-基]磺酰基]苯氧基]丙基]苯乙胺
- 化合物SR33805
- 121345-64-0
- Ca channels,channel,failing,Ca2+ channels,Ca2+,SR 33805,Calcium Channel,acute,L-type,SR-33805,Inhibitor,inhibit,depolarized,polarized,hearts,chronic,SR33805
- SR 33805