SR 33805
| 中文名称 | SR 33805 |
|---|---|
| 中文同义词 | 化合物SR33805;3,4-二甲氧基-N-甲基-N-[3-[4-[[1-甲基-2-2-(1-甲基乙基))-1H-吲哚-‐3-基]磺酰基]苯氧基]丙基]苯乙胺 |
| 英文名称 | SR 33805 |
| 英文同义词 | SR 33805;Ca channels,channel,failing,Ca2+ channels,Ca2+,SR 33805,Calcium Channel,acute,L-type,SR-33805,Inhibitor,inhibit,depolarized,polarized,hearts,chronic,SR33805 |
| CAS号 | 121345-64-0 |
| 分子式 | C32H40N2O5S |
| 分子量 | 564.7354 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 121345-64-0.mol |
| 结构式 |  |
SR 33805 性质
| 储存条件 | Store at -20°C |
|---|
|
L-type calcium channel 4.1 nM (EC 50 , in depolarized conditions) |
L-type calcium channel 33 nM (EC 50 , in polarized conditions) |
SR33805 (0.01-10 µM; 3 d) inhibits growth factor-induced proliferation of SMC (0.20
SR33805 (10 µM; 10 min) restores the myocardial infarction (MI)-altered cell shortening without affecting the Ca
2+
transient amplitude.
SR33805 (10 µM) decreases the activity of recombinant PKA.
Cell Viability Assay
| Cell Line: | Smooth muscle cells (SMC) |
| Concentration: | 0.01, 0.1, 1, 10 µM |
| Incubation Time: | 3 days |
| Result: | Inhibited in a dose-dependent manner FCS-, bFGF and PDGF-induced proliferation of porcine SMC with IC 50 s of 0.26±0.08, 0.46±0.1 and 0.20±0.04 µM, respectively. |
SR33805 (20 mg/kg; a single i.p.) improves end-systolic strain and fractional shortening of MI hearts in rats.
SR33805 (5 mg/kg/day; p.o. for 38 d) significantly reduces intimal hyperplasia in pigs.
| Animal Model: | Male Wistar rats (5 weeks) are subjected to coronary artery ligature |
| Dosage: | 0.2, 2, 20 mg/kg |
| Administration: | A single i.p. injection |
| Result: |
Increased significantly both end-systolic strain (ESS) and fractional shortening (FS) by about +38 and +26%, respectively at the dose of 20 mg/kg.
Did not affect other contractile parameters. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-136909 | SR33805 | 1 mg | 685元 | |
| 2024/04/30 | HY-136909 | SR 33805 SR33805 | 121345-64-0 | 10mg | 3000元 |