非诺班
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- CAS号:
- 57653-26-6
- 英文名:
- FENOBAM
- 英文别名:
- FENOBAM;Mcn-3377;1-(3-Chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea;1-(3-Chlorophenyl)-3-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea;N-(3-CHLOROPHENYL)-N'-(4,5-DIHYDRO-1-METHYL-4-OXO-1H-IMIDAZOL-2-YL)UREA;N-(3-CHLOROPHENYL)-N'-(4,5-DIHYDRO-1-METHYL-4-OXO-1H-IMIDAZOLE-2-YL)UREA;Urea, N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)-;Fenobam,anxiolytic,brain-penetrant,mGluR,nonbenzodiazepine,Inhibitor,addiction,inhibit,cocaine,Metabotropic glutamate receptors
- 中文名:
- 非诺班
- 中文别名:
- 非诺班;苯脲咪唑酮;FENOBAM,MGLU 5拮抗剂;1-(3-氯苯基)-3-(1-甲基-4-氧代-4,5-二氢-1H-咪唑-2-基)脲
- CBNumber:
- CB0155115
- 分子式:
- C11H11ClN4O2
- 分子量:
- 266.68
- MOL File:
- 57653-26-6.mol
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非诺班化学性质
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密度:
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1.47±0.1 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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DMSO: >20mg/mL
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酸度系数(pKa):
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8.32±0.20(Predicted)
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形态:
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solid
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颜色:
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white
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非诺班性质、用途与生产工艺
非诺班(Fenobam)是一种选择性、口服活性的、穿过血脑屏障的mGluR5 拮抗剂,其作用于变构调节位点 (在大鼠和人重组 mGlu5 受体上的 Kd 值分别 54 nM 和 31 nM)。Fenobam 具有反向激动剂活性,其阻断 mGlu5 受体活性。
rat mGluR5
54 nM (Kd)
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human mGluR5
31 nM (Kd)
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Fenobam sulfate (30-60 mg/kg; p.o.) significantly inhibited cocaine self-administration .
Animal Model:
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Male Long-Evans rats (250-300 g)
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Dosage:
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30-60 mg/kg
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Administration:
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P.o.
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Result:
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Inhibited cocaine self-administration
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非诺班
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-101478 | 非诺班 Fenobam | 57653-26-6 | 1mg | 400元 |
2024/08/19 | HY-101478 | 非诺班 Fenobam | 57653-26-6 | 5mg | 1050元 |
非诺班
生产厂家
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非诺班国内生产厂家
57653-26-6, 非诺班 相关搜索:
- Glutamate
- Glutamate receptor
- 合成有机化合物配体
- C11H11N4O2Cl
- C11H11ClN4O2
- 1-(3-氯苯基)-3-(1-甲基-4-氧代-4,5-二氢-1H-咪唑-2-基)脲
- FENOBAM,MGLU 5拮抗剂
- 非诺班
- 苯脲咪唑酮
- 57653-26-6
- 1-(3-Chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea
- Fenobam,anxiolytic,brain-penetrant,mGluR,nonbenzodiazepine,Inhibitor,addiction,inhibit,cocaine,Metabotropic glutamate receptors
- Urea, N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)-
- N-(3-CHLOROPHENYL)-N'-(4,5-DIHYDRO-1-METHYL-4-OXO-1H-IMIDAZOLE-2-YL)UREA
- N-(3-CHLOROPHENYL)-N'-(4,5-DIHYDRO-1-METHYL-4-OXO-1H-IMIDAZOL-2-YL)UREA
- Mcn-3377
- 1-(3-Chlorophenyl)-3-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea
- FENOBAM