PF03716556
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- CAS号:
- 928774-43-0
- 英文名:
- PF03716556
- 英文别名:
- CS-1022;PF 3716556;PF03716556;PF03716556 USP/EP/BP;PF-3716556 PF3716556;PF-03716556; PF03716556;PF3716556/PF-3716556/PF-03716556;PF-3716556;PF-03716556; PF03716556;(R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-ca;(R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide
- 中文名:
- PF03716556
- 中文别名:
- PF-03716556游离态;化合物PF 03716556;PF-3716556,H +,K + -ATPASE抑制剂;(R)-N-(2-羟乙基)-N,2-二甲基-8-((5-甲基苯并吡喃-4-基)氨基)咪唑并[1,2-A]吡啶-6-甲酰胺;8-[[(4R)-3,4-二氢-5-甲基-2H-1-苯并吡喃-4-基]氨基]-N-(2-羟基乙基)-N,2-二甲基咪唑并[1,2-A]吡啶-6-甲酰胺
- CBNumber:
- CB02526164
- 分子式:
- C22H26N4O3
- 分子量:
- 394.47
- MOL File:
- 928774-43-0.mol
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PF03716556化学性质
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熔点:
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143-145°C
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密度:
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1.30
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储存条件:
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Keep in dark place,Inert atmosphere,2-8°C
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溶解度:
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DMSO: ≥10mg/mL
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形态:
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powder
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酸度系数(pKa):
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14.18±0.10(Predicted)
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颜色:
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white to tan
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PF03716556性质、用途与生产工艺
PF-3716556是一种有效的，选择性的P-CAB钾离子竞争性酸抑制剂，在离子渗透和离子密集检测中，抑制猪H+，K+-ATPase活性，抑制胃酸分泌，对Na+，K+-ATPas没有作用活性，用于治疗胃食管返流疾病。
| Target | Value |
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H+/K+-ATPase
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~6.5(pIC50)
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PF-03716556是一种有效的，选择性耐酸泵拮抗剂，在离子渗透和离子密集检测中，抑制猪的
H
在大鼠和狗动物模型中，PF-03716556抑制胃酸分泌。PF-03716556具有长效作用，单次剂量下具有30分钟的最大作用效果，连续注射5天没有明显的耐药信号。
PF03716556
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | S2222 | PF03716556
PF-3716556 | 928774-43-0 | 10mg | 899.11元 |
| 2024/01/16 | S2222 | PF03716556
PF-3716556 | 928774-43-0 | 50mg | 3845.51元 |
928774-43-0, PF03716556 相关搜索:
- Pharmaceuticals
- Pfizer Compounds
- Intermediates & Fine Chemicals
- Inhibitors
- Heterocycles
- Aromatics
- Amines
- 药靶配体
- 膜转运
- 离子通道
- 信号转导通路激酶抑制剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- PF-3716556,H +,K + -ATPASE抑制剂
- (R)-N-(2-羟乙基)-N,2-二甲基-8-((5-甲基苯并吡喃-4-基)氨基)咪唑并[1,2-A]吡啶-6-甲酰胺
- PF-03716556游离态
- 化合物PF 03716556
- 8-[[(4R)-3,4-二氢-5-甲基-2H-1-苯并吡喃-4-基]氨基]-N-(2-羟基乙基)-N,2-二甲基咪唑并[1,2-A]吡啶-6-甲酰胺
- 928774-43-0
- PF-3716556 PF3716556
- (R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide
- PF03716556 USP/EP/BP
- Imidazo[1,2-a]pyridine-6-carboxamide, 8-[[(4R)-3,4-dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-
- CS-1022
- PF-03716556; PF03716556
- PF3716556/PF-3716556/PF-03716556
- (R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-ca
- PF-3716556;PF-03716556; PF03716556
- PF 3716556
- PF03716556
- [N-(2-Hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide]
- 8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethylimidazo[1,2-a]pyridine-6-carboxamide PF 03716556
- (R)-N-(2-hydroxyethyl)-N,2-dimethyl-8-(5-methyl-3,4-dihydro-2H-chromen-4-ylamino)H-imidazo[1,2-a]pyridine-6-carboxamide
- N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa
- 8-[[(4R)-3,4-Dihydro-5-Methyl-2H-1-benzopyran-4-yl]aMino]-N-(2-hydroxyethyl)-N,2-diMethyliMidazo[1,2-a]pyridine-6-carboxaMide