1,4-二亞硝哌【口+井】
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- CAS号:
- 140-79-4
- 英文名:
- N,N'-DINITROSOPIPERAZINE
- 英文别名:
- 1,4-DINITROSOPIPERAZINE;Dinitrosopiperazine;Dnpz;nsc339;NSC 339;usafdo-36;USAF do-36;Dinitrosopiperazin;TIMTEC-BB SBB008187;Piperazine Impurity 4
- 中文名:
- 1,4-二亞硝哌【口+井】
- 中文别名:
- 哌嗪杂质4;哌嗪杂质24;N,N-二硝基哌嗪;标准品RN1031;N,N-二亚硝基哌嗪;1,4-二亚硝基哌嗪;哌柏西利杂质IM-065;1,4-二亞硝哌【口+井】
- CBNumber:
- CB0420996
- 分子式:
- C4H8N4O2
- 分子量:
- 144.13
- MOL File:
- 140-79-4.mol
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1,4-二亞硝哌【口+井】化学性质
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熔点:
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208-210°C
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沸点:
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262.72°C (rough estimate)
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密度:
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1.4165 (rough estimate)
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折射率:
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1.8500 (estimate)
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储存条件:
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-20°C Freezer, Under Inert Atmosphere
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溶解度:
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Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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-4.82±0.70(Predicted)
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颜色:
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White to Pale Yellow
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水溶解性:
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5.765g/L(24 ºC)
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稳定性:
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Hygroscopic
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CAS 数据库:
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140-79-4
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EPA化学物质信息:
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Piperazine, 1,4-dinitroso- (140-79-4)
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1,4-二亞硝哌【口+井】性质、用途与生产工艺
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) 是一种致癌物 (carcinogen)，特异性针对鼻咽癌，可促进鼻咽癌的转移。N,N'-Dinitrosopiperazine 通过蛋白磷酸化调节多种信号通路，包括 LYRIC，在丝氨酸 568 位。
N,N'-Dinitrosopiperazine (0.5-100 μM; 48 hours) has no inhibitory effects on the labeled 6-10B cells, and LDH activity is not significantly altered by DNP treatment in the 0.5-8 μM concentration range. However, it is cytotoxic from the concentration 10 μM.N,N'-Dinitrosopiperazine (2-8 μM; 24 hours) induces 6-10B cell invasion and motility in a dose-dependent manner. At 6 μM, when compares to the control group, DNP increases cell invasion at 421.7% and cell motility is increased by 328.2%.N,N'-Dinitrosopiperazine (6 μM; 24 hours) increases the expression of phospho-LYRIC s568 and LYRIC expression in CNE1 cells.
Cell Viability Assay
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Cell Line:
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The labeled 6-10B cells
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Concentration:
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0.5, 1, 2, 4, 6, 8, 10, 20, 40, 80, or 100 μM
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Incubation Time:
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48 hours
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Result:
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Had no inhibitory effects at the concentration 0-8 μM.
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Western Blot Analysis
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Cell Line:
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The NPC cell line CNE1
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Concentration:
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6 μM
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Incubation Time:
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24 hours
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Result:
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Increased phospho-LYRIC s568 and LYRIC expression.
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N,N'-Dinitrosopiperazine (injected into the tail veins; 40 mg/kg; 30 days) inhibits cell motility and invasion, and facilitates NPC metastasis in vivo. From a IHC result, Phospho-LYRIC expression is higher in the metastatic tumors of DNP-treated mice than in those of the untreated control mice.
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Animal Model:
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BABL/c nude mice injected with labeled 6-10B cell suspensions (1 × 10
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cells) with or without DNP(40 mg/kg)
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Dosage:
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40 mg/kg
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Administration:
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Injected into the tail veins; 30 days
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Result:
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Induced LYRIC phosphorylation at serine 568 associated with NPC metastasis in vivo.
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1,4-二亞硝哌【口+井】
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-136433 | 1,4-二亞硝哌【口+井】
N,N'-Dinitrosopiperazine | 140-79-4 | 5 mg | 600元 |
| 2024/08/19 | HY-136433 | 1,4-二亞硝哌【口+井】
N,N'-Dinitrosopiperazine | 140-79-4 | 10 mg | 950元 |
140-79-4, 1,4-二亞硝哌【口+井】 相关搜索:
- Mutagenesis Research Chemicals
- Heterocycles
- 杂质对照品
- C4H8N2NO2
- 哌柏西利杂质IM-065
- N,N-二硝基哌嗪
- 标准品RN1031
- 哌嗪杂质4
- 哌嗪杂质24
- N,N-二亚硝基哌嗪
- 1,4-二亚硝基哌嗪
- 1,4-二亞硝哌【口+井】
- 140-79-4
- N,N'-Dinitrosopiperazine (DMP)
- N,N'-DINITROSOPIPERAZINE
- Piperazine Impurity 24
- 1,4-DINITROSOPIPERAZINE
- Dinitrosopiperazine
- N,N-Dinitroso-Piperazin
- Piperazine, 1,4-dinitroso-
- Piperazine Impurity 4
- N- Nitrosopiperazine DIMER
- 140-79-4---N,N'-DINITROSOPIPERAZINE
- 1,4-dinitrosopiperidine
- Dinitrosopiperazine: (Piperazine, 1,4-dinitroso-)
- usafdo-36
- USAF do-36
- nsc339
- NSC 339
- Dnpz
- Dinitrosopiperazin
- 1,4-dinitroso-piperazin
- TIMTEC-BB SBB008187
- N,N'-DINITROSOPIPERAZINE