DJ-V159
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- CAS号:
- 2253744-53-3
- 英文名:
- DJ-V159
- 英文别名:
- DJ-V159;DJ-V159;DJ-V 159;DJV159,Inhibitor,Androgen Receptor,inhibit,DJ V 159;1,3-Benzenedicarboxamide, N1,N3-bis[4-cyano-3-(trifluoromethyl)phenyl]-
- 中文名:
- DJ-V159
- 中文别名:
- 化合物DJ-V159;N1,N3-双(4-氰基-3-(三氟甲基)苯基)间苯二甲酰胺
- CBNumber:
- CB04804691
- 分子式:
- C24H12F6N4O2
- 分子量:
- 502.37
- MOL File:
- 2253744-53-3.mol
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DJ-V159化学性质
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储存条件:
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RT
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溶解度:
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Soluble in DMSO (up to 60 mg/ml).
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形态:
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solid
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颜色:
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Off-white
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稳定性:
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Stable for 2 years from date of purchase? as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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DJ-V159性质、用途与生产工艺
DJ-V-159 是G蛋白偶联受体家族C组6 A (GPRC6A) 的激动剂。
DJ-V-159 activates ERK in HEK-293 transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V-159 dose-dependently stimulates cAMP production in GPRC6A expressing HEK-293 cells, achieving a response a 0.2 nM concentrations in the media. DJ-V-159 stimulates insulin secretion in mouse beta-cell MIN-6 cells. The DJ-V-159 increased insulin stimulation index (SI) in MIN-6 cells similar to the effects of Ocn, known ligand of GPRC6A.
DJ-V-159 at the dose of 10 mg/kg reduces blood glucose levels in wildtype mice at 60 and 90 minutes after intraperitoneal administration of 10 mg/kg, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively, after intraperitoneal administration of 10 mg/kg. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five.
DJ-V159
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-114165 | DJ-V159 DJ-V-159 | 2253744-53-3 | 5mg | 420元 |
2024/04/30 | HY-114165 | DJ-V159 DJ-V-159 | 2253744-53-3 | 10mM * 1mLin DMSO | 464元 |
2253744-53-3, DJ-V159 相关搜索:
- 药靶配体
- N1,N3-双(4-氰基-3-(三氟甲基)苯基)间苯二甲酰胺
- 化合物DJ-V159
- 2253744-53-3
- DJV159,Inhibitor,Androgen Receptor,inhibit,DJ V 159
- 1,3-Benzenedicarboxamide, N1,N3-bis[4-cyano-3-(trifluoromethyl)phenyl]-
- DJ-V159;DJ-V 159
- DJ-V159