印楝素B
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- CAS号:
- 106500-25-8
- 英文名:
- AZADIRACHTIN B(SH)
- 英文别名:
- AZADIRACHTIN B(SH);Deacetylazadirachtinol;7H,8H-Furo[3',4':4,4a]naphtho[1,8-bc]furan-5,10a(1H)-dicarboxylic acid, octahydro-3,8-dihydroxy-4-methyl-10-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]-4-[(1aR,2S,3aS,6aS,7S,7aS)-3a,6a,7,7a-tetrahydro-6a-hydroxy-7a-methyl-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-, 5,10a-dimethyl ester, (2aR,3S,...
- 中文名:
- 印楝素B
- 中文别名:
- 印楝素B
- CBNumber:
- CB11266222
- 分子式:
- C33H42O14
- 分子量:
- 662.68
- MOL File:
- 106500-25-8.mol
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印楝素B化学性质
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沸点:
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780.5±60.0 °C(Predicted)
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密度:
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1.49±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Chloroform: slightly soluble; DMSO: slightly soluble; Methanol: slightly soluble
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形态:
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A solid
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酸度系数(pKa):
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11.99±0.60(Predicted)
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稳定性:
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Light Sensitive
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印楝素B性质、用途与生产工艺
Azadirachtin B 是从 Azadirachta indica 种子仁中分离的柠檬苦素。Azadirachtin B 增加碱性磷酸酶 (ALP) 活性并刺激成骨细胞分化。Azadirachtin B 对爱泼斯坦-巴尔病毒早期抗原 (EBV-EA) 具有活性。Azadirachtin B 具有杀虫，杀线虫，抗癌，抗炎，抗病毒和成骨特性。
Plutella xylostella
Alkaline phosphatase (ALP)
Epstein-Barr virus early antigen (EBV-EA)
Azadirachtin B (1 pM-100 µM; 48 hours; Osteoblast cells) treatment shows highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells.
Azadirachtin B increases expression of RunX-2 ∼2.5 fold at 10 nM concentration, ALP expression ∼2.8 fold at 10 nM and 100 pM concentration and OCN expression ∼2.5 folds at 10 nM as compared with control.
Azadirachtin B (Compound 4) exhibits toxicity to the diamondback moth (
Plutella xylostella
) with an LD
50
of 4.85-1.06 µg/g body weight, in 92 h.
Azadirachtin B (compound 21) exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA).
Cell Proliferation Assay
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Cell Line:
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Osteoblast cells
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Concentration:
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1 pM, 100 pM, 10 nM, 1 µM, 100 µM
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Incubation Time:
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48 hours
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Result:
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Showed highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells.
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On evaluation of Azadirachtin B (compound 21; oral administration) for its anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) as an initiator and TPA as a promoter, this exhibited marked inhibitory activity.
印楝素B
上下游产品信息
上游原料
下游产品
106500-25-8, 印楝素B 相关搜索:
- C33H42O14
- 印楝素B
- 106500-25-8
- 7H,8H-Furo[3',4':4,4a]naphtho[1,8-bc]furan-5,10a(1H)-dicarboxylic acid, octahydro-3,8-dihydroxy-4-methyl-10-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]-4-[(1aR,2S,3aS,6aS,7S,7aS)-3a,6a,7,7a-tetrahydro-6a-hydroxy-7a-methyl-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-, 5,10a-dimethyl ester, (2aR,3S,...
- Deacetylazadirachtinol
- AZADIRACHTIN B(SH)