印楝素B

印楝素B

中文名称印楝素B
中文同义词印楝素B
英文名称AZADIRACHTIN B(SH)
英文同义词AZADIRACHTIN B(SH);Deacetylazadirachtinol;7H,8H-Furo[3',4':4,4a]naphtho[1,8-bc]furan-5,10a(1H)-dicarboxylic acid, octahydro-3,8-dihydroxy-4-methyl-10-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]-4-[(1aR,2S,3aS,6aS,7S,7aS)-3a,6a,7,7a-tetrahydro-6a-hydroxy-7a-methyl-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-, 5,10a-dimethyl ester, (2aR,3S,...
CAS号106500-25-8
分子式C33H42O14
分子量662.68
EINECS号
相关类别
Mol文件106500-25-8.mol
结构式印楝素B 结构式

印楝素B 性质

沸点780.5±60.0 °C(Predicted)
密度1.49±0.1 g/cm3(Predicted)
储存条件Store at -20°C
溶解度氯仿:微溶; DMSO:微溶;甲醇:微溶
形态固体
酸度系数(pKa)11.99±0.60(Predicted)
颜色白色至米白色
稳定性感光

印楝素B 用途与合成方法

Azadirachtin B 是从 Azadirachta indica 种子仁中分离的柠檬苦素。Azadirachtin B 增加碱性磷酸酶 (ALP) 活性并刺激成骨细胞分化。Azadirachtin B 对爱泼斯坦-巴尔病毒早期抗原 (EBV-EA) 具有活性。Azadirachtin B 具有杀虫,杀线虫,抗癌,抗炎,抗病毒和成骨特性。

Plutella xylostella
Alkaline phosphatase (ALP)
Epstein-Barr virus early antigen (EBV-EA)

Azadirachtin B (1 pM-100 µM; 48 hours; Osteoblast cells) treatment shows highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells.
Azadirachtin B increases expression of RunX-2 ∼2.5 fold at 10 nM concentration, ALP expression ∼2.8 fold at 10 nM and 100 pM concentration and OCN expression ∼2.5 folds at 10 nM as compared with control.
Azadirachtin B (Compound 4) exhibits toxicity to the diamondback moth ( Plutella xylostella ) with an LD 50 of 4.85-1.06 µg/g body weight, in 92 h.
Azadirachtin B (compound 21) exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA).

Cell Proliferation Assay

Cell Line: Osteoblast cells
Concentration: 1 pM, 100 pM, 10 nM, 1 µM, 100 µM
Incubation Time: 48 hours
Result: Showed highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells.

On evaluation of Azadirachtin B (compound 21; oral administration) for its anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) as an initiator and TPA as a promoter, this exhibited marked inhibitory activity.

安全信息

MSDS信息

印楝素B 上下游产品信息

"印楝素B"相关产品信息
印楝素
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