嘧啶杂质1
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- CAS号:
- 1402452-15-6
- 英文名:
- 2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide
- 英文别名:
- ap261133;hSMG-1 inhibitor 11j;Pyrimidine Related Compound 1;hSMG 1 inhibitor 11j,hSMG1 inhibitor 11j;2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide;Benzenesulfonamide, 2-chloro-N,N-diethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-
- 中文名:
- 嘧啶杂质1
- 中文别名:
- 嘧啶杂质1;HSMG-1抑制剂11J
- CBNumber:
- CB12695063
- 分子式:
- C27H28ClN7O3S
- 分子量:
- 566.07
- MOL File:
- 1402452-15-6.mol
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嘧啶杂质1化学性质
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密度:
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1.353±0.06 g/cm3(Predicted)
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储存条件:
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4°C, away from moisture and light
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酸度系数(pKa):
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14.00±0.46(Predicted)
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嘧啶杂质1性质、用途与生产工艺
hSMG-1 inhibitor 11j,一种嘧啶衍生物,是有效的和选择性的 hSMG-1 抑制剂,IC50 值为 0.11 nM。hSMG-1 inhibitor 11j 对 hSMG-1 的选择性是 mTOR (IC50=50 nM),PI3Kα/γ (IC50=92/60 nM) 和 CDK1/CDK2 (IC50=32/7.1 μM) 的 455 倍以上。hSMG-1 inhibitor 11j 可用于癌症研究。
hSMG-1
0.11 nM (IC
50
)
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mTOR
50 nM (IC
50
)
|
PI3Kγ
60 nM (IC
50
)
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PI3Kα
92 nM (IC
50
)
|
GSKα
260 (IC
50
)
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GSKβ
330 (IC
50
)
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CDK2
7.1 μM (IC
50
)
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CDK1
32 μM (IC
50
)
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hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM, and eliminates it at 1 μM in MDA 361 cells.
hSMG-1 inhibitor 11j inhibits MDA468 cell proliferation, with an IC
50
of 75 nM.
嘧啶杂质1
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/01/25 | HY-124719 | hSMG-1 inhibitor 11j | | 1 mg | 1700元 |
2024/01/25 | HY-124719 | 嘧啶杂质1 hSMG-1 inhibitor 11j | 1402452-15-6 | 5mg | 4000元 |
1402452-15-6, 嘧啶杂质1 相关搜索:
- Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
- 小分子抑制剂
- C27H28ClN7O3S
- HSMG-1抑制剂11J
- 嘧啶杂质1
- 1402452-15-6
- hSMG 1 inhibitor 11j,hSMG1 inhibitor 11j
- hSMG-1 inhibitor 11j
- Benzenesulfonamide, 2-chloro-N,N-diethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-
- ap261133
- Pyrimidine Related Compound 1
- 2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide