嘧啶杂质1
| 中文名称 | 嘧啶杂质1 |
|---|---|
| 中文同义词 | 嘧啶杂质1;HSMG-1抑制剂11J |
| 英文名称 | 2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide |
| 英文同义词 | 2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide;Pyrimidine Related Compound 1;ap261133;Benzenesulfonamide, 2-chloro-N,N-diethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-;hSMG-1 inhibitor 11j;hSMG 1 inhibitor 11j,hSMG1 inhibitor 11j |
| CAS号 | 1402452-15-6 |
| 分子式 | C27H28ClN7O3S |
| 分子量 | 566.07 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds |
| Mol文件 | 1402452-15-6.mol |
| 结构式 |  |
嘧啶杂质1 性质
| 密度 | 1.353±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | 4°C, away from moisture and light |
| 酸度系数(pKa) | 14.00±0.46(Predicted) |
|
hSMG-1 0.11 nM (IC 50 ) |
mTOR 50 nM (IC 50 ) |
PI3Kγ 60 nM (IC 50 ) |
PI3Kα 92 nM (IC 50 ) |
GSKα 260 (IC 50 ) |
GSKβ 330 (IC 50 ) |
CDK2 7.1 μM (IC 50 ) |
CDK1 32 μM (IC 50 ) |
hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM, and eliminates it at 1 μM in MDA 361 cells.
hSMG-1 inhibitor 11j inhibits MDA468 cell proliferation, with an IC
50
of 75 nM.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-124719 | hSMG-1 inhibitor 11j | 1 mg | 1700元 | |
| 2024/01/25 | HY-124719 | 嘧啶杂质1 hSMG-1 inhibitor 11j | 1402452-15-6 | 5mg | 4000元 |