(5Z)-7-OXOZEAENOL
|
|
|
- CAS号:
- 253863-19-3
- 英文名:
- LL Z1640-2
- 英文别名:
- nol;C 292;L 783279;FR148083;f 152 A1;5Z-7-Oxoze&ÆTAK1 inhibitor 5ZO);5Z-7-Oxozeaenol >=98% (HPLC);1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-;(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
- 中文名:
- (5Z)-7-OXOZEAENOL
- 中文别名:
- (5Z)-7-氧杂烯醇;化合物5Z-7-OXOZEAENOL;5Z-7-OXOZE&ÆLIG;NOL
- CBNumber:
- CB12744545
- 分子式:
- C19H22O7
- 分子量:
- 362.37
- MOL File:
- 253863-19-3.mol
|
|
|
(5Z)-7-OXOZEAENOL化学性质
-
熔点:
-
171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
-
|
-
沸点:
-
666.8±55.0 °C(Predicted)
-
|
-
密度:
-
1.270±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
DMSO: >10mg/mL
-
|
-
形态:
-
powder
-
|
-
酸度系数(pKa):
-
7.32±0.70(Predicted)
-
|
-
颜色:
-
white to off-white
-
|
(5Z)-7-OXOZEAENOL性质、用途与生产工艺
5Z-7-Oxozeaneol 是一种天然的抗原生动物化合物，为有效的，不可逆的，选择性的 TAK1 和 VEGF-R2 抑制剂，IC50 值分别为 8 nM 和 52 nM。
|
TAK1
8.1 nM (IC
50
)
|
VEGFR-2
52 nM (IC
50
)
|
VEGFR-3
110 nM (IC
50
)
|
FLT3
170 nM (IC
50
)
|
PDGFR-β
340 nM (IC
50
)
|
B-RAF VE
6300 nM (IC
50
)
|
SRC
6600 nM (IC
50
)
|
MEK1
411 nM (IC
50
)
|
5Z-7-Oxozeaenol is a potent irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 (TAK1, IC
50
, 8.1 nM), less active on MEK1 (IC
50
, 411 nM). 5Z-7-Oxozeaenol prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. 5Z-7-Oxozeaenol is also an inhibitor of VEGF-R2, with an IC
50
of 52 nM. 5Z-7-Oxozeaenol has inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE and SRC, with IC
50
s of 110, 170, 340, 6300 and 6600 nM, respectively. 5Z-7-Oxozeaenol inhibits JNK/p38 paythway, but it is not a direct inhibitor and is signal specific. 5Z-7-Oxozeaenol suppresses the PMA-induced AP-1 activity almost to the basal level in the KT cells, but has no effects on IL-1-induced NF-kB activity in the KK cells.
(5Z)-7-OXOZEAENOL
上下游产品信息
上游原料
下游产品
253863-19-3, (5Z)-7-OXOZEAENOL 相关搜索:
- 制剂-抑制剂
- 对照品
- 微生物代谢物
- 5Z-7-OXOZE&ÆLIG;NOL
- (5Z)-7-氧杂烯醇
- 化合物5Z-7-OXOZEAENOL
- 253863-19-3
- 5Z-7-Oxoze&Æ
- nol
- 5Z-7-Oxozeaenol >=98% (HPLC)
- 1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-
- TAK1 inhibitor 5ZO)
- (2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
- L 783279
- FR148083
- C 292
- f 152 A1