化合物 T19230
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- CAS号:
- 1313730-14-1
- 英文名:
- Teijin compound 1
- 英文别名:
- CCR2 antagonist 4 HCl;CCR2 antagonist 4 hydrochloride;CCR2 antagonist 4 hydrochloride,CCR-2 antagonist 4 hydrochloride
- 中文名:
- 化合物 T19230
- 中文别名:
- 化合物 T19230
- CBNumber:
- CB13311670
- 分子式:
- C21H22Cl2F3N3O2
- 分子量:
- 476.32
- MOL File:
- 1313730-14-1.mol
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化合物 T19230化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble to 10 mM in water and to 100 mM in DMSO
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形态:
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Powder
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化合物 T19230性质、用途与生产工艺
CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) 是一种高效、特异的 CCR2 拮抗剂，对 CCR2b 的 IC50 值为 180 nM。CCR2 antagonist 4 hydrochloride 对 MCP-1 诱导的趋化作用有较强的抑制作用，其 IC50 为 24 nM。
Ile263 and Thr292 in CCR2 contribute significantly to binding of CCR2 antagonist 4 in CCR2. Residue Glu291 in TM7, a highly conserved residue in many CC chemokine receptors, contributes substantially to binding of the protonated CCR2 antagonist 4 hydrochloride, and CCL2. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4 hydrochloride.
In ApoE-deficient mice, Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 hydrochloride reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta.
化合物 T19230
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-103362 | 化合物 T19230
CCR2 antagonist 4 hydrochloride | 1313730-14-1 | 5mg | 1100元 |
| 2024/04/30 | HY-103362 | 化合物 T19230
CCR2 antagonist 4 hydrochloride | 1313730-14-1 | 10mM * 1mLin DMSO | 1210元 |
1313730-14-1, 化合物 T19230 相关搜索:
- 药靶配体
- C21H21ClF3N3O2HCl
- C21H22Cl2F3N3O2
- 化合物 T19230
- 1313730-14-1
- CCR2 antagonist 4 HCl
- CCR2 antagonist 4 hydrochloride,CCR-2 antagonist 4 hydrochloride
- CCR2 antagonist 4 hydrochloride