化合物 T10895
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- CAS号:
- 2375740-98-8
- 英文名:
- 1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-
- 英文别名:
- 1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-
- 中文名:
- 化合物 T10895
- 中文别名:
- 化合物CSN5I-3;化合物 T10895
- CBNumber:
- CB18233045
- 分子式:
- C28H29F2N5O2
- 分子量:
- 505.56
- MOL File:
- 2375740-98-8.mol
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化合物 T10895化学性质
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沸点:
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666.5±55.0 °C(Predicted)
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密度:
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1.35±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C, protect from light, stored under nitrogen
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溶解度:
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DMSO:50.56(Max Conc. mg/mL);100.0(Max Conc. mM)
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酸度系数(pKa):
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12.66±0.70(Predicted)
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化合物 T10895性质、用途与生产工艺
CSN5i-3 是一种有效的，选择性和口服的 CSN5/Jab1 抑制剂，抑制 CSN 催化的 Cul1 deneddylation IC50 值为 5.8 nM。
CSN5i-3 traps CRLs in the neddylated state, which leads to inactivation of a subset of CRLs by inducing degradation of their substrate recognition module.
CSN5i-3 shows a good pharmacokinetic profile. CSN5i-3 inhibits growth of human xenograft. Treatment with CSN5i-3 triggers the formation of cleaved PARP and cleaved caspase 3 indicative of apoptosis induction.
化合物 T10895
上下游产品信息
上游原料
下游产品
2375740-98-8, 化合物 T10895 相关搜索:
- C28H29F2N5O2
- 化合物CSN5I-3
- 化合物 T10895
- 2375740-98-8
- 1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-