化合物 T10895
中文名称 | 化合物 T10895 |
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中文同义词 | 化合物 T10895;化合物CSN5I-3;3-(二氟甲基)-N-(6-((5S,6S)-6-羟基-6,7,8,9-四氢-5H-咪唑并[1,5-A]氮杂卓-5-基)-[1,1'-联苯]-3-基)-1-异丙基-1H-吡唑-5-甲酰胺 |
英文名称 | 1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]- |
英文同义词 | 1H-Pyrazole-5-carboxamide, 3-(difluoromethyl)-1-(1-methylethyl)-N-[6-[(5S,6S)-6,7,8,9-tetrahydro-6-hydroxy-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl]-;3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,1'-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide |
CAS号 | 2375740-98-8 |
分子式 | C28H29F2N5O2 |
分子量 | 505.56 |
EINECS号 | |
相关类别 | |
Mol文件 | 2375740-98-8.mol |
结构式 |
化合物 T10895 性质
沸点 | 666.5±55.0 °C(Predicted) |
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密度 | 1.35±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C, protect from light, stored under nitrogen |
溶解度 | DMSO:50.56(最大浓度 mg/mL);100.0(最大浓度 mM) |
酸度系数(pKa) | 12.66±0.70(Predicted) |
形态 | 固体 |
颜色 | 浅黄至黄色 |
CSN5i-3 是一种有效的,选择性和口服的 CSN5/Jab1 抑制剂,抑制 CSN 催化的 Cul1 deneddylation IC50 值为 5.8 nM。
IC50: 5.8 nM (CSN5)
CSN5i-3 traps CRLs in the neddylated state, which leads to inactivation of a subset of CRLs by inducing degradation of their substrate recognition module.
CSN5i-3 shows a good pharmacokinetic profile. CSN5i-3 inhibits growth of human xenograft. Treatment with CSN5i-3 triggers the formation of cleaved PARP and cleaved caspase 3 indicative of apoptosis induction.