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(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
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- CAS号:
- 187523-35-9
- 英文名:
- (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
- 英文别名:
- MaxiPost;FLINDOKALNER;BMS-204352
(BMS 204352;Flindokalner
BMS-204352;(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one;(3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one;2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (3S)-;inhibit,KcsA,Flindokalner,neuronal,ventricular,effects,BMS204352,anxiolytic,subtype,Potassium Channel,Inhibitor,BMS 204352,myocytes,current
- 中文名:
- (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
- 中文别名:
- MAXIPOST,钾通道调节剂;化合物FLINDOKALNER
- CBNumber:
- CB21253977
- 分子式:
- C16H10ClF4NO2
- 分子量:
- 359.7
- MOL File:
- 187523-35-9.mol
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(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one化学性质
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沸点:
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436.9±45.0 °C(Predicted)
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密度:
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1.50±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble to 100 mM in DMSO and to 100 mM in ethanol
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形态:
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Powder
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酸度系数(pKa):
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10.43±0.40(Predicted)
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(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one性质、用途与生产工艺
Flindokalner (BMS-204352) 是钾离子通道 (potassium channel) 调节剂。Flindokalner 是在 HEK293 细胞中表达的所有神经元 Kv7 通道亚型的正调节剂。Flindokalner 是一种大电导钙激活 K 通道 (BKca) 正向调节剂。Flindokalner 在 Kv7.1 通道 (Ki=3.7 μM) 处显示负调节活性，并充当 GABAA 受体的负调节剂。Flindokalner 在体内显示出抗焦虑功效。
Ki: 3.7 μM (Kv7.1), 230 μM (Kv7.4), 605 μM (Kv7.5)
Flindokalner (BMS-204352) (10 μM) inhibits Kv7.4and Kv7.5 with K
i
s of 230 and 605 μM, respectively.
Flindokalner (1-10 μM) causes inhibition of the Ca
2+
current in a dose-dependent manner, with a Kd of 6 μM and a Hill coefficient of 1.33. Flindokalnerinhibits cardiac L-type Ca
2+
channels in a direct manner, without affecting BKCa channels or intracellular signal transduction, in freshly isolated rat ventricular myocytes.
Flindokalner (BMS-204352) (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect.
In shock-based conditioned model of anxiety in male Wistar rats, Flindokalner (3-60 mg/kg; i.p.) engenderes an anxiolytic profile.
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Animal Model:
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Female NMRI or male C57 mice (20-25 g) (Anxiolytic Models)
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Dosage:
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i.p.
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Administration:
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3, 10, 30 mg/kg
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Result:
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Significantly and dose dependently increased time spent in the open areas, reduced latency to enter an open area, and increased the number of entries in to the open areas in Zero Maze.
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(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-108584 | (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
Flindokalner | 187523-35-9 | 5mg | 1600元 |
| 2024/04/30 | HY-108584 | (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
Flindokalner | 187523-35-9 | 10mM * 1mLin DMSO | 1760元 |
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
生产厂家
187523-35-9, (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one 相关搜索:
- 合成有机化合物配体
- C16H10ClF4NO2
- MAXIPOST,钾通道调节剂
- 化合物FLINDOKALNER
- 187523-35-9
- inhibit,KcsA,Flindokalner,neuronal,ventricular,effects,BMS204352,anxiolytic,subtype,Potassium Channel,Inhibitor,BMS 204352,myocytes,current
- Flindokalner
BMS-204352
- 2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (3S)-
- BMS-204352
(BMS 204352
- (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
- MaxiPost
- FLINDOKALNER
- (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one