雌莫司汀磷酸钠
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- CAS号:
- 52205-73-9
- 英文名:
- Estramustine sodium phosphate
- 英文别名:
- emcyt;C13031;Estracyt;NSC 89199;iumphosphate;Ro 21-8837/001;estracytsodium;4-(550-Butyl)phenol;Estramustin sodium phosphate;ESTRAMUSTINE PHOSPHATE SODIUM
- 中文名:
- 雌莫司汀磷酸钠
- 中文别名:
- 雌莫司丁磷酸钠;雌莫司汀磷酸钠;雌莫司汀磷酸钠, 抗微管蛋白化疗试剂
- CBNumber:
- CB2127417
- 分子式:
- C23H33Cl2NNaO6P
- 分子量:
- 544.38
- MOL File:
- 52205-73-9.mol
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雌莫司汀磷酸钠性质、用途与生产工艺
Estramustine phosphate sodium (EMP, Emcyt, Estracyt)是一种具有独特双重作用模式的抗肿瘤药。Estramustine phosphate sodium的代谢产物estrone和estradiol具有抗促性腺激素的活性，导致睾丸激素水平降低。Estramustine(estramustine phosphate sodium去磷酸化作用产生的细胞毒性代谢产物)是一种具有抗微管作用的抗前列腺肿瘤药物。
Estramustine phosphate sodium (1 µg/mL) treatment suppressed PC3 cell growth.
Estramustine phosphate sodium (2 µg/mL) treatment significantly elevates phosphatidylserine eversion amount on PC3 cells. Estramustine phosphate sodium induces PC3 cell apoptosis.
Estramustine phosphate sodium (2 µg/mL) treatment decreases MiR-31 level. Estramustine phosphate odium induces s prostate cancer cell line PC3 apoptosis through reducing miR-31.
Estramustine phosphate sodium, a unique antitumour agent, is selectively taken up by prostate cells and exerts antineoplastic effects by interfering with microtubule of dynamics and by reducing plasma levels of testosterone.
Estrone and estradiol, products of the metabolism of Estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels similar to those achieved after surgical castration.
Estramustine phosphate sodium (4-12 mg/kg; intraperitoneal injection; daily; for 2 weeks) inhibits PAC120 tumor growth 53% by day 35.
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Animal Model:
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Swiss nu/nu (nude) male mice (5-week-old) bearing PAC120 tumors
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Dosage:
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4 mg/kg, 12 mg/kg
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Administration:
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Intraperitoneal injection; daily; for 2 weeks
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Result:
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Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
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雌莫司汀磷酸钠
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-13627 | Estramustine phosphate sodium | | 5 mg | 360元 |
| 2024/01/25 | HY-13627 | 雌莫司汀磷酸钠
Estramustine phosphate sodium | 52205-73-9 | 10mM * 1mLin Water | 447元 |
52205-73-9, 雌莫司汀磷酸钠 相关搜索:
- Other APIs
- Intermediates
- Active Pharmaceutical Ingredients
- 药靶配体
- 化学试剂
- 医药、农药及染料中间体
- 医药原料药
- C23H30Cl2NO6P2Na
- C23H32NO6PNa
- C23H30Cl2NNa2O6P
- 55205-73-9
- 雌莫司汀磷酸钠, 抗微管蛋白化疗试剂
- 雌莫司丁磷酸钠
- 雌莫司汀磷酸钠
- 52205-73-9
- 4-(550-Butyl)phenol
- Estramustine sodium phosphateQ: What is
Estramustine sodium phosphate Q: What is the CAS Number of
Estramustine sodium phosphate Q: What is the storage condition of
Estramustine sodium phosphate
- Estramustin sodium phosphate
- Estramustine sodium phosphate USP/EP/BP
- disodium [3-[bis(2-chloroethyl)amino-oxomethoxy]-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] phosphate
- Estramustine Phosphate (sodium salt)
- Estramustine sodium phosphate, 97%, antimicrotubule chemotherapy agent
- estramustinephosphatedisodium
- estracytsodium
- estra-1,3,5(10)-triene-3,17-beta-diol3-(bis(2-chloroethyl)carbamate)17-disod
- emcyt
- Estradiol 3-bis(2-chloroethyl)carbamate 17-(dihydrogen phosphate) sodium salt
- Estra-1,3,5(10)triene-3,17-diol 3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate) sodium salt
- Estra-1,3,5(10)-triene-3,17-diol(17b)-,3-[N,N-bis(2-chloroethyl)carbaMate] 17-(dihydrogen phosphate), sodiuM salt(1:2)
- Estramustine Sodium Phosphate & Estramustine Base
- C13031
- 1,3,5(10)-Estratriene-3,17β-diol 3-[bis(2-chloroethyl)carbamate]17-[phosphoric acid disodium] salt
- 3,5(10)-triene-3,17-diol(17-beta)-estra-3-(bis(2-chloroethyl)carbamate)17
- ESTRAMUSTINE SODIUM PHOSPHATE
- (17-beta)-Estra-1,3,5(10)-triene-3,17-diol 3-(bis(2-chloroethyl)carbamate) 17-(dihydrogenphosphate) disodium salt
- Estra-1,3,5(10)-trien-3,17-diol-(17beta)-, 3-(Bis(2-chlorethyl)carbamat) 17-(Dihydrogen-phosphat), Dinatriumsalz
- Ro 21-8837/001
- NSC 89199
- Estramustine phosphate disodium salt
- Estracyt
- Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt
- Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt
- iumphosphate
- -(dihydrogenphosphate),disodiumsalt
- ESTRAMUSTINE PHOSPHATE SODIUM