延命草素
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- CAS号:
- 3776-39-4
- 英文名:
- enmein
- 英文别名:
- enmein;Isodonin
- 中文名:
- 延命草素
- 中文别名:
- 延命素;延命草素;延命素,延命草素
- CBNumber:
- CB21379525
- 分子式:
- C20H26O6
- 分子量:
- 362.42
- MOL File:
- 3776-39-4.mol
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延命草素化学性质
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熔点:
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274-276℃ (Decomposition) (ethanol )
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沸点:
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610.3±55.0 °C(Predicted)
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密度:
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1.37±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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12.66±0.60(Predicted)
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延命草素性质、用途与生产工艺
Enmein 从 I. serra 中分离，具有免疫抑制作用。
Enmein shows significant inhibitory effect toward K562 with an IC
50
value ranging from 3.2 μg/ml to 8.2 μg/ml.
Enmein (3.13-25 μg/ml; 48 hours) has inhibitory effect on lymphocytes with significant difference within concentration from 6.25 μg/ml to 25 μg/ml.
Enmein (5.5-22 μg/ml; 48 hours) causes the percentage of S stage cells decreased from 19% to 6%, causes the percentage of G2/M stage cells to decrease from 2% to 0.4%.
Cell Viability Assay
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Cell Line:
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Splenic lymphocyte cells
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Concentration:
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3.13, 6.25, 12.5, 25 μg/ml
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Incubation Time:
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48 hours
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Result:
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Exhibited an IC
50
value of 17 μg/ml in splenic lymphocytes.
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Cell Cycle Analysis
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Cell Line:
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Splenic lymphocyte cells
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Concentration:
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5.5 μg/ml, 11 μg/ml, 22 μg/ml
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Incubation Time:
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48 hours
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Result:
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Caused S stage cells and G2/M stage cells decreased.
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Enmein (inject to ear; 6.52-13.04 mg/kg; 5 days) inhibits the xylene-induced ear swelling and inhibits IL-2 expression.
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Animal Model:
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Balb/c mice
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Dosage:
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6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg
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Administration:
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Injected to ear; 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg; 5 days
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Result:
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Had inhibitory effect on IL-2 release in blood.
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化学性质
白色针状色结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于溪黄草。
延命草素
上下游产品信息
上游原料
下游产品
3776-39-4, 延命草素 相关搜索:
- 标准品 -中药标准品
- 二萜
- 对照品
- 中药对照品
- 延命素,延命草素
- 延命素
- 延命草素
- 3776-39-4
- Isodonin
- enmein