SULFOSUCCINIMIDYL OLEATE
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- CAS号:
- 135661-44-8
- 英文名:
- Sulfosuccinimidyl Oleate Sodium
- 英文别名:
- Sulfosuccinimidyl Oleate;Sulfosuccinimidyl Oleate Sodium;Sulfo-N-succinimidyl Oleate sodium;Sulphosuccinimyl oleate sodium salt;3-Pyrrolidinesulfonic acid, 2,5-dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-;inhibit,Sulfosuccinimidyl oleate,Mitochondrial Autophagy,Inhibitor,Mitophagy;(Z)-2,5-Dioxo-1-[(1-oxo-9-octadecenyl)oxy]-3-pyrrolidinesulfonic Acid Sodium;2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-3-pyrrolidinesulfonic Acid Sodium;2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]pyrrolidine-3-sulphonic acid sodium salt
- 中文名:
- SULFOSUCCINIMIDYL OLEATE
- 中文别名:
- 化合物 T13036;磺基琥珀酰亚胺油酸钠;磺基琥珀酰亚胺基油酸酯;化合物SULFOSUCCINIMIDYL OLEATE;化合物SULFOSUCCINIMIDYL OLEATE SODIUM
- CBNumber:
- CB21564909
- 分子式:
- C22H37NO7S
- 分子量:
- 459.6
- MOL File:
- 135661-44-8.mol
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SULFOSUCCINIMIDYL OLEATE化学性质
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熔点:
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220-2220C
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密度:
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1.19±0.1 g/cm3(Predicted)
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储存条件:
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-20°C Freezer
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溶解度:
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DMSO (Slightly), Methanol (Slightly, Heated)
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形态:
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Solid
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酸度系数(pKa):
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-0.04±0.20(Predicted)
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颜色:
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White to Off-White
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稳定性:
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Hygroscopic
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SULFOSUCCINIMIDYL OLEATE性质、用途与生产工艺
Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) 是一种长链脂肪酸，抑制脂肪酸向细胞转运。Sulfosuccinimidyl oleate 是一种有效且不可逆的线粒体呼吸链抑制剂。Sulfosuccinimidyl oleate 结合小胶质细胞表面上的 CD36 受体。具有抗炎作用。
Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability.
Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours).
Cell Viability Assay
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Cell Line:
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BV2 cells
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Concentration:
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20 μM and 50 μM
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Incubation Time:
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24 hours
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Result:
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Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it.
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Western Blot Analysis
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Cell Line:
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BV2 cells
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Concentration:
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50 μM
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Incubation Time:
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24 hours
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Result:
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Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.
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Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke.
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Animal Model:
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4-month-old male BALB/cABom mice with pMCAo model
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Dosage:
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50 mg/kg
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Administration:
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Administered once by single oral gavage
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Result:
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Reduced brain damage following ischemia. Attenuated infarct size.
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SULFOSUCCINIMIDYL OLEATE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-112847A | SULFOSUCCINIMIDYL OLEATE
Sulfosuccinimidyl oleate sodium | 135661-44-8 | 5mg | 1900元 |
| 2024/04/30 | HY-112847A | SULFOSUCCINIMIDYL OLEATE
Sulfosuccinimidyl oleate sodium | 135661-44-8 | 10mM * 1mLin DMSO | 2090元 |
SULFOSUCCINIMIDYL OLEATE
生产厂家
135661-44-8, SULFOSUCCINIMIDYL OLEATE 相关搜索:
- Sulfur & Selenium Compounds
- Heterocycles
- Glycerols
- Fatty Acid Derivatives & Lipids
- Heterocyclic Compounds
- 高端化学
- C22H37NO7S
- C22H36NNaO7S
- 磺基琥珀酰亚胺油酸钠
- 化合物SULFOSUCCINIMIDYL OLEATE
- 磺基琥珀酰亚胺基油酸酯
- 化合物SULFOSUCCINIMIDYL OLEATE SODIUM
- 化合物 T13036
- 135661-44-8
- inhibit,Sulfosuccinimidyl oleate,Mitochondrial Autophagy,Inhibitor,Mitophagy
- Sulfo-N-succinimidyl Oleate sodium
- 3-Pyrrolidinesulfonic acid, 2,5-dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-
- Sulfosuccinimidyl Oleate Sodium
- 2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-3-pyrrolidinesulfonic Acid Sodium
- 2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]pyrrolidine-3-sulphonic acid sodium salt
- Sulphosuccinimyl oleate sodium salt
- Sulfosuccinimidyl Oleate
- (Z)-2,5-Dioxo-1-[(1-oxo-9-octadecenyl)oxy]-3-pyrrolidinesulfonic Acid Sodium