TCN-201
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- CAS号:
- 852918-02-6
- 英文名:
- 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
- 英文别名:
- TCN 201;TCN 201-d5;N-[[4-(benzamidocarbamoyl)phenyl]methyl]-3-chloro-4-fluorobenzenesulfonamide;N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonaMide;4-[[[(3-Chloro-4-fluorophenyl)sulfonyl]aMino]Methyl]benzoic Acid 2-Benzoylhydrazide;3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide;Benzoic acid, 4-[[[(3-chloro-4-fluorophenyl)sulfonyl]amino]methyl]-, 2-benzoylhydrazide;TCN 201,GluN1,Inhibitor,GluN2A,inhibit,iGluR,Ionotropic glutamate receptors,NMDAR,TCN201;3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide;TCN-201 N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4-
fluorobenzenesulfonaMide
- 中文名:
- TCN-201
- 中文别名:
- N-(4-(2-苯甲酰肼羰基)苄基)-3-氯-4-氟苯磺酰胺;4-[[[(3-氯-4-氟苯基)磺酰基]氨基]甲基]苯甲酸 2-苯甲酰基酰肼
- CBNumber:
- CB22518750
- 分子式:
- C21H17ClFN3O4S
- 分子量:
- 461.89
- MOL File:
- 852918-02-6.mol
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TCN-201化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble5mg/mL (clear solution)
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形态:
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powder
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颜色:
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white to beige
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TCN-201性质、用途与生产工艺
TCN 201 是一种有效的,选择性和非竞争性的 GluN1/GluN2A NMDA 受体拮抗剂,pIC50 值为 6.8。与 GluN1/GluN2B NMDA 受体 (pIC50<4.3) 相比,TCN 201 对 GluN1/GluN2A NMDA 受体具有选择性。
pIC50: 6.8 (GluN1/GluN2A NMDA receptor)
TCN 201 (compound 1) is selective for GluN1/GluN2A NMDAR over GluN1/GluN2B NMDAR, with pIC
50
s of 6.8 and <4.3, respectively.
TCN 201 (10 μM) produces only slight inhibition of GluN1/GluN2B NMDAR-mediated currents in oocytes.
TCN 201 (10-30 μM) antagonism of NMDAR-mediated responses is both subtype- and glycine-dependent and more potent than TCN 213 in oocytes.
TCN 201 (0.1-100 μM) does not produce complete block of NMDAR-mediated responses in oocytes.
TCN 201 (10 μM) antagonism of NMDAR-mediated currents shows a negative correlation with their ifenprodil sensitivity in rat cortical neurons.
TCN 201 (1-9 μM) suppresses cortical spreading depression (CSD) in chick retina.
TCN-201 (10 mg/kg; i.p.) is ineffective in CSD blood-oxygen level-dependent (BOLD) response in rats.
TCN-201
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-13457 | TCN 201 | | 1 mg | 242元 |
2024/08/19 | HY-13457 | TCN 201 | | 5 mg | 605元 |
852918-02-6, TCN-201 相关搜索:
- Sulfur & Selenium Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Aromatics
- Amines
- 合成有机化合物配体
- C21H17ClFN3O4S
- N-(4-(2-苯甲酰肼羰基)苄基)-3-氯-4-氟苯磺酰胺
- 4-[[[(3-氯-4-氟苯基)磺酰基]氨基]甲基]苯甲酸 2-苯甲酰基酰肼
- 852918-02-6
- TCN 201,GluN1,Inhibitor,GluN2A,inhibit,iGluR,Ionotropic glutamate receptors,NMDAR,TCN201
- Benzoic acid, 4-[[[(3-chloro-4-fluorophenyl)sulfonyl]amino]methyl]-, 2-benzoylhydrazide
- N-[[4-(benzamidocarbamoyl)phenyl]methyl]-3-chloro-4-fluorobenzenesulfonamide
- 3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide
- TCN-201 N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4-
fluorobenzenesulfonaMide
- TCN 201-d5
- 4-[[[(3-Chloro-4-fluorophenyl)sulfonyl]aMino]Methyl]benzoic Acid 2-Benzoylhydrazide
- N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonaMide
- TCN 201
- 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide