222989-99-3
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- CAS号:
- 222989-99-3
- 英文名:
- Finasteride (acetate)
- 英文别名:
- MK-906 acetate;Finasteride (acetate)
- 中文名:
- 222989-99-3
- 中文别名:
- 醋酸非那雄胺;醋酸非那斯特萊;化合物 T21668
- CBNumber:
- CB22677068
- 分子式:
- C25H40N2O4
- 分子量:
- 432.61
- MOL File:
- 222989-99-3.mol
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222989-99-3化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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222989-99-3性质、用途与生产工艺
Finasteride (MK-906) acetate 是一种有效的竞争性 5α-还原酶 (5α-reductase) 抑制剂，对 II 型 5α-还原酶的 IC50 值为 4.2 nM。Finasteride acetate 对 II 型 5α-还原酶的亲和力比对 I 型酶高约 100 倍。Finasteride acetate 可用于研究前列腺增生 (BPH) 和雄激素性脱发。
IC50: 4.2 nM (type II 5α-reductase)
Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells.
Finasteride decreases the conversion of [
3
H]testosterone (T) to [
3
H]dihydrotestosterone (DHT) in
P. crustosum
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Cell Viability Assay
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Cell Line:
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PC-3, DU-145, and LNCaP cells
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Concentration:
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10 μM
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Incubation Time:
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6, 12, 24 h
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Result:
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Increased the expression of HO-1 protein in a time-dependent manner in PC-3 cells.
Induced the expression of Nrf2 protein in DU-145 and PC-3 cells, but not in LNCaP cells.
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Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration.
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Animal Model:
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Male dogs with spontaneous BPH (2.7-11 years old; 10.3-49 kg)
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Dosage:
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0.1-0.5 mg/kg
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Administration:
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P.o. once daily for 16 weeks
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Result:
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Decreased prostatic diameter (20%), prostatic volume (43%), and serum DHT concentration (58%).
Decreased semen volume but did not adversely effect on semen quality or serum testosterone concentration.
No adverse effects on dogs.
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222989-99-3
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上游原料
下游产品
222989-99-3, 222989-99-3 相关搜索:
- 化合物 T21668
- 醋酸非那雄胺
- 醋酸非那斯特萊
- 222989-99-3
- MK-906 acetate
- Finasteride (acetate)