CZC-54252
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- CAS号:
- 1191911-27-9
- 英文名:
- CZC-54252
- 英文别名:
- CS-1730;CZC-54252;CZC-54252, >98%;CZC 54252;CZC54252;CZC 54252 hydrochloride;N-(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)pyrimidin-4-ylamino)phenyl)methanesulfonamide;LRRK2,LRRK2-G2019S,inhibit,neuronal,CZC-54252,injury,neuroprotective,Leucine-rich repeat kinase 2,Inhibitor;N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide;Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-;N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride
- 中文名:
- CZC-54252
- 中文别名:
- 化合物CZC-54252;N-(2-((5-氯-2-((2-甲氧基-4-吗啉苯基)氨基)嘧啶-4-基)氨基)苯基)甲磺酸
- CBNumber:
- CB22738769
- 分子式:
- C22H25ClN6O4S
- 分子量:
- 504.99
- MOL File:
- 1191911-27-9.mol
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CZC-54252化学性质
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沸点:
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718.1±70.0 °C(Predicted)
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密度:
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1.452±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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DMF: 20 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 10 mg/mL
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形态:
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Powder
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酸度系数(pKa):
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8.50±0.10(Predicted)
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CZC-54252性质、用途与生产工艺
CZC-54252是一种有效的LRRK2抑制剂，对人源野生型LRRK2和G2019S LRRK2的IC50分别为1.28 nM和1.85 nM。
| Target | Value |
LRRK2 (WT)
(Cell-free assay)
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1.28 nM
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LRRK2 (G2019S)
(Cell-free assay)
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1.85 nM
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CZC-54252 inhibits the activity of recombinant human wild-type LRRK2 with an IC
50
ranging from ～1 to ～5 nM. The G2019S mutant is inhibited with an IC
50
ranging from ～2 to ～7 nM in a TF-FRET assay. In addition, they are screened against a kinase panel of 185 kinases and exhibited good selectivity.
G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 with an EC
50
of ~1 nM and fully reversed to wild-type levels by CZC-54252 at concentration of 1.6 nM.
CZC-54252
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-B0792A | CZC-54252 hydrochloride | | 5 mg | 720元 |
| 2024/01/25 | HY-B0792 | CZC-54252 | | 5 mg | 720元 |
1191911-27-9, CZC-54252 相关搜索:
- Inhibitors
- 药靶配体
- 小分子抑制剂，天然产物
- 抑制剂
- 小分子抑制剂
- C22H25ClN6O4SHCl
- C22H25ClN6O4S
- 化合物CZC-54252
- N-(2-((5-氯-2-((2-甲氧基-4-吗啉苯基)氨基)嘧啶-4-基)氨基)苯基)甲磺酸
- 1191911-27-9
- LRRK2,LRRK2-G2019S,inhibit,neuronal,CZC-54252,injury,neuroprotective,Leucine-rich repeat kinase 2,Inhibitor
- N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide
- Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-
- CZC-54252, >98%
- CZC 54252;CZC54252
- N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride
- CS-1730
- CZC-54252
- CZC 54252 hydrochloride
- N-(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)pyrimidin-4-ylamino)phenyl)methanesulfonamide