CTLA-4 - INHIBITOR
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- CAS号:
- 635324-72-0
- 英文名:
- 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
- 英文别名:
- MDK24720;CTLA-4 - INHIBITO;CTLA-4 inhibitor 1;CTLA-4 - INHIBITOR;MDK 24720 (CTLA-4 inhibitor);B7/CD28 interaction inhibitor 1;2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b;2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one;2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one;2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one
- 中文名:
- CTLA-4 - INHIBITOR
- 中文别名:
- 化合物CTLA-4 INHIBITOR;PERFEMIKER]CTLA-4-INHIBITOR,98%;2-(4-氟苯基)-6-甲基-4-(3-(三氟甲基)苯基)-1,2-二氢二吡唑并[3,4-B:3',4'-D]吡啶-3(6H)-酮
- CBNumber:
- CB23048865
- 分子式:
- C21H13F4N5O
- 分子量:
- 427.35
- MOL File:
- 635324-72-0.mol
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CTLA-4 - INHIBITOR化学性质
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沸点:
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599.5±60.0 °C(Predicted)
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密度:
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1.54±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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酸度系数(pKa):
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5.76±0.20(Predicted)
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形态:
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Solid
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颜色:
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Off-white to light yellow
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CTLA-4 - INHIBITOR性质、用途与生产工艺
MDK 24720 (CTLA-4 inhibitor, copmound 6b) 是一种 Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4, CD152) 的抑制剂,对B7.1–CD28的抑制作用的IC50值为50 nM。
Target | Value |
CD152
()
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B7.1–CD28
(Cell-free assay)
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50 nM
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Bivalent CTLA4 homodimers bridge bivalent B7.1 homodimers to form an unusually stable signaling complex. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases.
CTLA-4 - INHIBITOR
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-102090 | B7/CD28 interaction inhibitor 1 | | 1 mg | 940元 |
2024/08/19 | HY-102090 | CTLA-4 - INHIBITOR B7/CD28 interaction inhibitor 1 | 635324-72-0 | 5mg | 2338元 |
635324-72-0, CTLA-4 - INHIBITOR 相关搜索:
- C21H13F4N5O
- PERFEMIKER]CTLA-4-INHIBITOR,98%
- 化合物CTLA-4 INHIBITOR
- 2-(4-氟苯基)-6-甲基-4-(3-(三氟甲基)苯基)-1,2-二氢二吡唑并[3,4-B:3',4'-D]吡啶-3(6H)-酮
- 635324-72-0
- 2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one
- 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
- MDK 24720 (CTLA-4 inhibitor)
- B7/CD28 interaction inhibitor 1,antibodies,T-cell,Inhibitor,inhibit,CTLA-4,responses,immunosuppression,B7.1,B-7/CD28 interaction inhibitor 1,CD28
- MDK24720
- B7/CD28 interaction inhibitor 1
- Dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one, 2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]-
- 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b
- CTLA-4 inhibitor 1
- CTLA-4 - INHIBITO
- 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
- CTLA-4 - INHIBITOR