CTLA-4 - INHIBITOR
| 中文名称 | CTLA-4 - INHIBITOR |
|---|---|
| 中文同义词 | 2-(4-氟苯基)-6-甲基-4-(3-(三氟甲基)苯基)-1,2-二氢二吡唑并[3,4-B:3',4'-D]吡啶-3(6H)-酮;化合物CTLA-4 INHIBITOR;PERFEMIKER]CTLA-4-INHIBITOR,98% |
| 英文名称 | 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one |
| 英文同义词 | CTLA-4 - INHIBITOR;2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one;CTLA-4 - INHIBITO;CTLA-4 inhibitor 1;2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b;Dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one, 2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]-;B7/CD28 interaction inhibitor 1;MDK24720 |
| CAS号 | 635324-72-0 |
| 分子式 | C21H13F4N5O |
| 分子量 | 427.35 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 635324-72-0.mol |
| 结构式 |  |
CTLA-4 - INHIBITOR 性质
| 沸点 | 599.5±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.54±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 酸度系数(pKa) | 5.76±0.20(Predicted) |
MDK 24720 (CTLA-4 inhibitor, copmound 6b) 是一种 Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4, CD152) 的抑制剂，对B7.1–CD28的抑制作用的IC50值为50 nM。
| Target | Value |
|
CD152
() | |
|
B7.1–CD28
(Cell-free assay) | 50 nM |
Bivalent CTLA4 homodimers bridge bivalent B7.1 homodimers to form an unusually stable signaling complex. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-102090 | B7/CD28 interaction inhibitor 1 | 1 mg | 940元 | |
| 2024/04/30 | HY-102090 | CTLA-4 - INHIBITOR B7/CD28 interaction inhibitor 1 | 635324-72-0 | 10mM * 1mLin DMSO | 2590元 |